Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes
Author | Dosekova, Erika |
Author | Filip, Jaroslav |
Author | Bertok, Tomas |
Author | Both, Peter |
Author | Kasak, Peter |
Author | Tkac, Jan |
Available date | 2020-10-01T11:39:53Z |
Publication Date | 2017 |
Publication Name | Medicinal Research Reviews |
Resource | Scopus |
Abstract | This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery. The final part of the review describes various ways in which glycan enrichment can be effectively done using nanomaterials, molecularly imprinted polymers with polymer thickness controlled at the nanoscale, with a subsequent analysis of glycans by mass spectrometry. A short section describing an active glycoprofiling by microengines (microrockets) is covered as well. |
Sponsor | This publication was made possible by NPRP grant number 6-381-1-078 from the Qatar National Research Fund (a member of the Qatar Foundation) |
Language | en |
Publisher | John Wiley and Sons Inc. |
Subject | cell tissue targeting/imaging and drug delivery glycan enrichment and active glycoprofiling glycan sensing glycan-based vaccines/therapeutics glycomics nanomaterials nanotechnology |
Type | Article Review |
Pagination | 514-626 |
Issue Number | 3 |
Volume Number | 37 |
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