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AuthorAshraf, Abugroun
AuthorTaha, Ahmed
AuthorAbdel-Rahman, Manar
AuthorPatel, Pragnesh
AuthorAli, Ibtisam
AuthorKlein, Lloyd W
Available date2020-10-06T05:01:23Z
Publication Date2020-09-15
Publication NameThe American Journal of Cardiology
Identifierhttp://dx.doi.org/10.1016/j.amjcard.2020.09.021
CitationAbugroun, A., Taha, A., Abdel-Rahman, M., Patel, P., Ali, I., & Klein, L. W. (2020). Cardiovascular Risk Among Patients≥ 65 Years of Age with Parkinson's Disease (From the National Inpatient Sample). The American Journal of Cardiology.
ISSN00029149
URIhttps://www.sciencedirect.com/science/article/pii/S0002914920309590?v=s5
URIhttp://hdl.handle.net/10576/16369
AbstractIn this study, we aimed to investigate the relationship between PD and vascular disease and risk factors using a nationally representative sample. The National Inpatient Sample (NIS) was queried for all patients aged ≥ 65 who were diagnosed with PD during the year 2016. Patients were identified using the International Classification of Diseases—Tenth Revision (ICD-10) diagnosis code: "G20". Each patient diagnosed with PD was frequency-matched to controls at a 1:4 ratio by age and gender. Study outcomes were hypertension, hyperlipidemia, diabetes mellitus, coronary artery disease and stroke. Outcomes were modeled using logistic regression analysis and further validation was obtained using a propensity score-matched analysis. A total of 57,914 patients (weighted: 289,570) with PD were included. Most patients were of Caucasian race (80.8%). Females were 42.4% and the mean age was 79 years, standard error of the mean (SEM) (0.03). PD correlated with lower odds for hyperlipidemia adjusted odd ratio (a-OR): 0.77 (0.75-0.79) p < 0.001, diabetes mellitus a-OR 0.73 (95%CI: 0.71-0.75) p < 0.001, hypertension a-OR 0.68 (95%CI: 0.67- 0.70) p < 0.001, coronary artery disease a-OR 0.64 (95%CI: 0.63-0.66) p < 0.001 and higher odds for stroke a-OR: 1.27 (95%CI: 1.24-1.31) p < 0.001. Following propensity score matching, identical findings were found. In conclusion, patients with PD have a distinct cardiovascular profile with higher rates of stroke and lower rates of coronary artery disease and vascular disease risk factors.
Languageen
PublisherElsevier
SubjectParkinson's disease
cardiovascular risk factors
Autonomic nervous system
National inpatient sample
TitleCardiovascular Risk Among Patients ≥ 65 Years of Age with Parkinson's Disease (From the National Inpatient Sample)
TypeArticle
dc.accessType Abstract Only


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