Targeting DNA Repair Pathways in Hematological Malignancies.
المؤلف | Alhmoud, Jehad F |
المؤلف | Mustafa, Ayman G |
المؤلف | Malki, Mohammed Imad |
تاريخ الإتاحة | 2020-10-11T08:33:59Z |
تاريخ النشر | 2020-10-01 |
اسم المنشور | International Journal of Molecular Sciences |
المعرّف | http://dx.doi.org/10.3390/ijms21197365 |
الاقتباس | Alhmoud JF, Mustafa AG, Malki MI. Targeting DNA Repair Pathways in Hematological Malignancies. International Journal of Molecular Sciences. 2020; 21(19):7365. |
الرقم المعياري الدولي للكتاب | 1661-6596 |
الملخص | DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent findings and highlights the importance of DNA repair components and the impact of their aberrations on hematological malignancies. |
اللغة | en |
الناشر | MDPI |
الموضوع | DNA damage DNA repair apoptosis hematological malignancies mutation |
النوع | Article Review |
رقم العدد | 19 |
رقم المجلد | 21 |
ESSN | 1422-0067 |
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