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Induction of Glyoxalase 1 to prevent Methylglyoxal-Induced Insulin Resistance in Cardiomyocytes
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Qatar University Press
, 2020 , Poster)
Background: Type 2 Diabetes mellitus is characterized by hyperglycemia and insulin resistance. Methylglyoxal (MG) a highly reactive dicarbonyl compound is also increased in diabetes. MG is detoxified by glyoxalase 1 (Glo-1) ...
Investigating the cardiac effects of Sildenafil loaded nanoparticles on heart failure using the Zebrafish Embryo Model.
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Qatar University Press
, 2020 , Poster)
Background: Cardiovascular diseases (CVDs) are the first cause of death worldwide. Vasolidator agents are used to relax cardiac muscle, but their extremely short half-lifes limit their effectiveness. Sildenafil is such an ...
Investigating the Cardiac Effects of New Generation Anti-Diabetic Drug EmpagliflozinUsing Zebrafish Embryo Model
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Qatar University Press
, 2020 , Poster)
Type 2 diabetes mellitus (T2DM) affects >16% of adults in Qatar. Newly emerging class of anti-diabetic drugs focuses on SGLT inhibition were observed to reduce CVDs risks in diabetic patients. Up to date, the mechanism ...
Toxicity Evaluation of Stearamidopropyl Dimethylamine Surfactant on Embryonic Development of Zebrafish
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Qatar University Press
, 2020 , Poster)
Background: Surfactants best known for their use in the industry of detergents, household products, and cosmetics. Usually, the amount of released surfactants into the environment is diluted during secondary water treatment. ...
Hepatic Gene Expression Profile of Lipid Metabolism of Obese Mice After Treatment with AntiObesity Drug
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Qatar University Press
, 2020 , Poster)
Obesity is a global disorder with multifactorial causes. The liver plays a vital role in fat metabolism. Disorder of hepatic fat metabolism is associated with obesity and causes fatty liver. High fat diet intake (HFD) to ...
Glucose and transferrin liganded PLGA nanoparticles internalization in non-small cell lung cancer cells
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Qatar University Press
, 2020 , Poster)
Introduction: Recently, after a decade of confusing results, several studies pointed out that overexpression of GLUT1 (glucose transporter 1) is a biomarker of worse prognosis in NSCLC. Nonetheless, the presence of Transferrin ...
Effect of hyperglycemia on EPCs function and regenerative ability
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Qatar University Press
, 2020 , Poster)
Diabetes induced hyperglycemia increases the risk of cardiovascular complications as it impacts vascular endothelial cells causing vascular dysfunction. Endothelial progenitor cells (EPCs) have been suggested to participate ...
The Use of Drosophila Melanogaster as A Model Organism To Study The Effect Of Innate Immunity On Metabolism
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Qatar University Press
, 2020 , Poster)
Apart from its traditional role in disease control, recent body of evidence has
implicated a role of the immune system in regulating metabolic homeostasis. Owing to
the importance of this “immune-metabolic alignment” ...
Development and in Vitro Testing of a Nitric Oxide Nanoparticle Carrier for Acute Lung Injury
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Qatar University Press
, 2020 , Poster)
Acute respiratory distress syndrome (ARDS) is an infectious clinical condition in which gas exchange inside the airways and alveoli are disturbed. Fluid filled lungs need to be mechanically ventilated for airway ...
PAMAM Dendrimers as Anti-HER2 Positive Breast Cancer Treatment
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Qatar University Press
, 2020 , Poster)
Background: Poly (amidoamine) dendrimers (PAMAMs) are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects like modulating gene expression, particularly ...