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AuthorAl-Jaber, Hend Sultan
AuthorAl-Mansoori, Layla Jadea
AuthorElRayess, Mohamed Aghar
Available date2020-10-26T08:49:53Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationAlJaber H.S., AlMansoori L.J., ElRayess M.A., "The Role of GATA3 in Adipogenesis & Insulin Resistance", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0143
URIhttps://doi.org/10.29117/quarfe.2020.0143
URIhttp://hdl.handle.net/10576/16726
AbstractBackground: Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. In hyperglycemia, immune system is activated partially through upregulation of GATA3, causing exacerbation of the inflammatory state associated with obesity. GATA3 also plays a role as a gatekeeper of terminal adipocyte differentiation. Here we are examining the impact of GATA3 inhibition in adipose tissue on restoring adipogenesis, reversing insulin resistance and potentially lowering the risk of type 2 diabetes. Results: GATA-3 expression was higher in insulin resistant obese individuals compared to their insulin sensitive counterparts. Targeting GATA-3 with GATA-3 specific inhibitors reversed impaired adipogenesis and induced changes in the expression of a number insulin signaling-related genes, including up-regulation of insulin sensitivity-related gene and down-regulation of insulin resistance-related genes. Conclusion: GATA3 expression is higher in differentiating adipocytes from obese insulin resistant. Inhibiting GATA3 improves adipocytes differentiation and rescues insulin sensitivity in insulin resistant cells.
Languageen
PublisherQatar University Press
SubjectGATA3
Insulin
Diabetes
Adipogenesis
Obesity
TitleThe Role of GATA3 in Adipogenesis & Insulin Resistance
TypePoster
dc.accessType Open Access


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