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المؤلفGhantous, Crystal M
المؤلفKamareddine, Layla
المؤلفFarhat, Rima
المؤلفZouein, Fouad A
المؤلفMondello, Stefania
المؤلفKobeissy, Firas
المؤلفZeidan, Asad
تاريخ الإتاحة2020-12-06T06:06:34Z
تاريخ النشر2020-11-01
اسم المنشورBiomedicines
المعرّفhttp://dx.doi.org/10.3390/biomedicines8120552
الاقتباسGhantous, C.M.; Kamareddine, L.; Farhat, R.; Zouein, F.A.; Mondello, S.; Kobeissy, F.; Zeidan, A. Advances in Cardiovascular Biomarker Discovery. Biomedicines 2020, 8, 552.
معرّف المصادر الموحدhttp://hdl.handle.net/10576/17200
الملخصCardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart failure and stroke. Identifying novel and early stage biomarkers of hypertension and other cardiovascular diseases is of paramount importance in predicting and preventing the major morbidity and mortality associated with these diseases. Biomarkers of such diseases or predisposition to their development are identified by changes in a specific indicator's expression between healthy individuals and patients. These include changes in protein and microRNA (miRNA) levels. Protein profiling using mass spectrometry and miRNA screening utilizing microarray and sequencing have facilitated the discovery of proteins and miRNA as biomarker candidates. In this review, we summarized some of the different, promising early stage protein and miRNA biomarker candidates as well as the currently used biomarkers for hypertension and other cardiovascular diseases. Although a number of promising markers have been identified, it is unlikely that a single biomarker will unambiguously aid in the classification of these diseases. A multi-marker panel-strategy appears useful and promising for classifying and refining risk stratification among patients with cardiovascular disease.
راعي المشروعThis research was funded by Qatar University [Grant QUERG-CMED-2020-3].
اللغةen
الناشرMDPI
الموضوعbiomarkers
cardiovascular diseases
hypertension
miRNA
proteomics
العنوانAdvances in Cardiovascular Biomarker Discovery.
النوعArticle Review
رقم العدد12
رقم المجلد8
ESSN2227-9059
dc.accessType Open Access


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