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المؤلفKohil, Amira
المؤلفAl-Asmakh, Maha
المؤلفAl-Shafai, Mashael
المؤلفTerranegra, Annalisa
تاريخ الإتاحة2021-01-31T10:41:08Z
تاريخ النشر2021-01-28
اسم المنشورFrontiers in Nutrition
الاقتباسKohil A, Al-Asmakh M, Al-Shafai M and Terranegra A (2021) The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes. Front. Nutr. 7:612115. doi: 10.3389/fnut.2020.612115
المعرّف612115
معرّف المصادر الموحدhttp://hdl.handle.net/10576/17551
الملخصThe autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex disease due to the interaction between genetic and environmental factors. Certain dietary patterns and nutrients are known to cause epigenetic modifications in physiological conditions and diseases. However, the interplay between diet and epigenetics is not yet well-understood in the context of T1DM. Several studies have described epigenetic mechanisms involved in the autoimmune reactions that destroy the β-cells, but few explored diet components as potential triggers for epigenetic modifications. Clarifying the link between diet and epigenome can provide new insights into the pathogenesis of T1DM, potentially leading to new diagnostic and therapeutic approaches. In this mini review, we shed light on the influence of the diet-epigenome axis on the pathophysiology of T1DM.
راعي المشروعThis study was funded by student grant from Qatar University (QUST-1-CHS-2020-5) and by Sidra Medicine internal funds (SDR200010/SDR400131).
اللغةen
الناشرFrontiers
الموضوعDiabetes
epigenetics
diet
العنوانThe Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes
النوعArticle Review
رقم المجلد7
dc.accessType Open Access


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