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المؤلفYou, Zhou
المؤلفZhu, Bo
المؤلفLin, Lifeng
المؤلفKwong, Joey S.W.
المؤلفXu, Chang
تاريخ الإتاحة2021-02-07T11:20:45Z
تاريخ النشر2020-12-31
اسم المنشورJournal of Clinical Epidemiology
المعرّفhttp://dx.doi.org/10.1016/j.jclinepi.2020.09.023
الاقتباسZhou, Y., Zhu, B., Lin, L., Kwong, J. S., & Xu, C. (2020). Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events. Journal of Clinical Epidemiology, 128, 109-117.
الرقم المعياري الدولي للكتاب08954356
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0895435620311094
معرّف المصادر الموحدhttp://hdl.handle.net/10576/17561
الملخصObjectivesMeta-analyses of rare events often generate unstable results, and selective reporting of the results may mislead the health care decision. Developing a synthesis plan for rare events in protocol may help to formulate the reporting. We aim to investigate whether existing protocols specified methods to deal with rare events. Study Design and SettingProtocols (not including Cochrane protocols) for systematic reviews of health care interventions focused on the safety registered in PROSPERO were included. The proportion of protocols that specified methods to deal with rare events and the detailed methods were summarized. We compared the difference of proportions (PD) across different settings. ResultsWe identified 1,004 eligible protocols, of which, 119 (11.85%, 95% confidence interval (CI): 9.92%, 14.01%) specified methods to deal with rare events. The three most commonly planned methods were the Mantel–Haenszel, Peto's odds ratio, and continuity correction. Protocols planned a quantitative analysis (PD = 0.07, 95% CI: 0.02, 0.12; P = 0.004) and listed safety as a primary outcome (PD = 0.07, 95% CI: 0.01, 0.12; P = 0.018) were more likely to specify methods to deal with rare events. ConclusionProtocols for systematic reviews of intervention safety seldom specified methods to deal with rare events. Future systematic reviewers should provide a detailed and rigorous synthesis plan for rare events in their protocols.
اللغةen
الناشرElsevier
الموضوعProtocols
Meta-analysis of rare events
Data synthesis plan
PROSPERO
العنوانProtocols for meta-analysis of intervention safety seldom specified methods to deal with rare events
النوعArticle Review
الصفحات109-117
رقم المجلد128
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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