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AuthorMajdalawieh, Amin F
AuthorYousef, Sarah M
AuthorAbu-Yousef, Imad A
AuthorNasrallah, Gheyath K
Available date2021-02-10T09:25:32Z
Publication Date2021-02-01
Publication NameCritical Reviews in Food Science and Nutrition
Identifierhttp://dx.doi.org/10.1080/10408398.2021.1881438
CitationAmin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef & Gheyath K. Nasrallah (2022) Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions, Critical Reviews in Food Science and Nutrition, 62:18, 5081-5112, DOI: 10.1080/10408398.2021.1881438
ISSN1040-8398
URIhttp://hdl.handle.net/10576/17671
AbstractInflammation is associated with the development and progression of various disorders including atherosclerosis, diabetes mellitus and cancer. Sesamin, a fat-soluble lignan derived from seeds and oil, has received increased attention due to its wide array of pharmacological properties including its immunomodulatory and anti-inflammatory potential. To date, no review has been conducted to summarize or analyze the immunomodulatory and anti-inflammatory roles of sesamin. Herein, we provide a comprehensive review of experimental findings that were reported with regards to the ability of sesamin to modulate inflammation, cellular and humoral adaptive immune responses and Th1/Th2 paradigm. The potential influence of sesamin on the cytotoxic activity of NK cells against cancer cells is also highlighted. The molecular mechanisms and the signal transduction pathways underlying such effects are underscored. The metabolism, pharmacokinetics, absorption, tissue distribution and bioavailability of sesamin in different species, including humans, are reviewed. Moreover, we propose future preclinical and clinical investigations to further validate the potential preventive and/or therapeutic efficacy of sesamin against various immune-related and inflammatory conditions. We anticipate that sesamin may be employed in future therapeutic regimens to enhance the efficacy of treatment and dampen the adverse effects of synthetic chemical drugs currently used to alleviate immune-related and inflammatory conditions.
Languageen
PublisherTaylor and Francis
SubjectSesamum indicum
Sesamin
Th1/Th1 paradigm
anti-inflammatory
bioavailability
immunomodulatory
TitleImmunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions.
TypeArticle
Pagination1-32
Pagination5081-5112
Issue Number18
Volume Number62
ESSN1549-7852
dc.accessType Full Text


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