Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines
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عرض / فتح
التاريخ
2020-11-13المؤلف
Wang, Hung KaiChio, Yu Lun
Pallikonda, Gangaram
Wu, Hsyueh Liang
Su, Haw Lih
Hsieh, Jen Chieh
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure.
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- أبحاث وحدة المختبرات المركزية [91 items ]