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المؤلفMohamed Qasim, Al-Fahdawi
المؤلفAl-Doghachi, Faris A.J.
المؤلفAbdullah, Qasim Khlaif
المؤلفHammad, Ruaa Tareq
المؤلفRasedee, Abdullah
المؤلفIbrahim, Wisam Nabeel
المؤلفAlshwyeh, Hussah Abdullah
المؤلفAlosaimi, Areej A
المؤلفAldosary, Sahar Khamees
المؤلفEid, Eltayeb E.M.
المؤلفRosli, Rozita
المؤلفTaufiq-Yap, Y.H.
المؤلفAl-Haj, Nagi A.
المؤلفAl-Qubaisi, Mothanna Sadiq
تاريخ الإتاحة2021-03-21T04:48:44Z
تاريخ النشر2021-06-30
اسم المنشورBiomedicine & Pharmacotherapy
المعرّفhttp://dx.doi.org/10.1016/j.biopha.2021.111483
الرقم المعياري الدولي للكتاب07533322
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0753332221002687
معرّف المصادر الموحدhttp://hdl.handle.net/10576/17933
الملخصThe aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The chemical compositions, functional groups, and size of nanoparticles were determined using X-ray diffraction, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, and scanning electron microscopy. Pt/MgO nanoparticles were cuboid and in the nanosize range of 30–50 nm. The cytotoxicity of Pt/MgO nanoparticles was determined via the 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyltetrazolium bromide assay on the human lung and colonic cancer cells (A549 and HT29 respectively) and normal human lung and colonic fibroblasts cells (MRC-5 and CCD-18Co repectively). The Pt/MgO nanoparticles were relatively innocuous to normal cells. Pt/MgO nanoparticles downregulated Bcl-2 and upregulated Bax and p53 tumor suppressor proteins in the cancer cells. Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. Thus, the anticancer effects of Pt/MgO nanoparticles were attributed to the induction of oxidative stress and apoptosis. The study showed the potential of Pt/MgO nanoparticles as an anti-cancer compound.
اللغةen
الناشرElsevier
الموضوعPt/MgO nanoparticles
Cytotoxicity
Oxidative stress
Lipid peroxidation
Apoptosis
Lung cancer
Colonic cancer
العنوانOxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
النوعArticle
رقم المجلد138
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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