SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections
Author | Farhan, Cyprian |
Author | Sohail, Muhammad Umar |
Author | Abdelhafez, Ibrahim |
Author | Salman, Salma |
Author | Attique, Zakria |
Author | Kamareddine, Layla |
Author | Al-Asmakh, Maha |
Available date | 2021-03-25T06:35:51Z |
Publication Date | 2021-04-30 |
Publication Name | International Journal of Infectious Diseases |
Identifier | http://dx.doi.org/10.1016/j.ijid.2021.02.071 |
Citation | Cyprian F, Sohail MU, Abdelhafez I, Salman S, Attique Z, Kamareddine L, Al-Asmakh M. SARS-CoV-2-Immune-Microbiome Interaction: Lessons from Respiratory Viral Infections. Int J Infect Dis. 2021 Feb 18;105:540–50. doi: 10.1016/j.ijid.2021.02.071. |
ISSN | 12019712 |
Abstract | By the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted many existing flaws within public healthcare systems across the world. While coronavirus disease 2019 (COVID-19) is bestowed with a broad spectrum of clinical manifestations, involving the vital organs, the respiratory system transpires as the main route of entry for SARS-CoV-2, with the lungs being its primary target. Of those infected, up to 20% require hospitalization on account of severity, while the majority of patients are either asymptomatic or exhibit mild symptoms. Exacerbation in the disease severity and complications of COVID-19 infection have been associated with multiple comorbidities, including hypertension, diabetes mellitus, cardiovascular disorders, cancer, and chronic lung disease. Interestingly, a recent body of evidence indicated the pulmonary and gut microbiomes as potential modulators for altering the course of COVID-19, potentially via the microbiome-immune system axis. While the relative concordance between microbes and immunity has yet to be fully elucidated with regards to COVID-19, we present an overview of our current understanding of COVID-19-microbiome-immune cross talk and discuss the potential contributions of microbiome-related immunity to SARS-CoV-2 pathogenesis and COVID-19 disease progression. |
Language | en |
Publisher | Elsevier |
Subject | SARS-CoV-2 COVID-19 Respiratory tract microbiome Gut microbiome Immunity |
Type | Article |
Pagination | 540-550 |
Volume Number | 105 |
Open Access user License | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Biomedical Sciences [697 items ]
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COVID-19 Research [802 items ]