Targeted delivery of rifampicin to tuberculosis-infected macrophages: design, in-vitro, and in-vivo performance of rifampicin-loaded poly(ester amide)s nanocarriers
المؤلف | Praphakar, Rajendran Amarnath |
المؤلف | Munusamy, Murugan A. |
المؤلف | Sadasivuni, Kishor Kumar |
المؤلف | Rajan, Mariappan |
تاريخ الإتاحة | 2021-04-11T11:07:19Z |
تاريخ النشر | 2016 |
اسم المنشور | International Journal of Pharmaceutics |
المصدر | Scopus |
الملخص | We have developed a nano drug delivery system for the treatment of tuberculosis (TB) using rifampicin (RF) encapsulated in poly(ester amide)s nanoparticles (PEA-RF-NPs), which are biocompatible polymers. In this study, biodegradable amino acid based poly(ester amide)s (PEAs) were synthesized by the poly condensation reaction and RF-loaded NPs were fabricated by the dialysis method. The surface morphology and in-vitro drug release efficiency were examined. The effect of time and temperature on the cellular uptake of PEA-RF-NPs in NR8383 cells was evaluated. Fluorescence microscopic results of PEA-RF-NPs from NR8383 cell lines suggest its potential application in treating TB. The antibacterial activity of RF against Mycobacterium smegmatis was also evaluated. Based on these results, this approach provides a new means for controlled and efficient release of RF using the PEA-NPs delivery system and is promising for the treatment of TB. |
راعي المشروع | M. Rajan is grateful to the DST-SERB, Government of India, for financial support under the scheme of �EMEQ� (F.No.- SB/EMEQ-241-2014) and University Grants Commission UGC-MRP scheme Ref: No. F.43-187/2014 (SR), New Delhi. The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding of this research through Research Group project No. RG-1435-057. M. Rajan thanks the DST-FIST program for the purchase of an FTIR, SEM, and the UGC, for funds under UPE programs for the purchase of a TEM. |
اللغة | en |
الناشر | Elsevier B.V. |
الموضوع | Alveolar macrophages Mycobacterium smegmatis Nanoparticles Polyesteramides Rifampicin Tuberculosis |
النوع | Article |
الصفحات | 628-635 |
رقم العدد | 2-Jan |
رقم المجلد | 513 |
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