Open-label study of absorption and clearance of 1% voriconazole eye drops
| Author | Neoh, Chin Fen |
| Author | Leung, Lok |
| Author | Chan, Elsie |
| Author | Al-Badriyeh, Daoud |
| Author | Fullinfaw, Robert O. |
| Author | Jhanji, Vishal |
| Author | Vajpayee, Rasik B. |
| Author | Davies, Geoffrey E. |
| Author | Stewart, Kay |
| Author | Kong, David C. M. |
| Available date | 2021-04-22T13:00:31Z |
| Publication Date | 2016 |
| Publication Name | Antimicrobial Agents and Chemotherapy |
| Resource | Scopus |
| Abstract | Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis. |
| Language | en |
| Publisher | American Society for Microbiology |
| Subject | eye drops voriconazole antifungal agent eye drops voriconazole adult aged aqueous humor Article cataract extraction clinical article drug absorption drug clearance drug elimination drug half life elective surgery elimination half-life elimination rate constant female high performance liquid chromatography human in vitro study infection prevention keratomycosis male middle aged minimum inhibitory concentration open study paracentesis postoperative infection priority journal very elderly clinical trial drug effects Adult Aged Aged, 80 and over Antifungal Agents Aqueous Humor Cataract Extraction Female Humans Male Middle Aged Ophthalmic Solutions Voriconazole |
| Type | Article |
| Pagination | 6896-6898 |
| Issue Number | 11 |
| Volume Number | 60 |
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Pharmacy Research [1311 items ]