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AuthorAlser, Maha
AuthorShurbaji, Samar
AuthorYalcin, Huseyin C
Available date2021-04-29T09:35:04Z
Publication Date2021-03-01
Publication NameJournal of Cardiovascular Development and Disease
Identifierhttp://dx.doi.org/10.3390/jcdd8040032
CitationAlser, M.; Shurbaji, S.; Yalcin, H.C. Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies. J. Cardiovasc. Dev. Dis. 2021, 8, 32. https://doi.org/10.3390/jcdd8040032
URIhttp://hdl.handle.net/10576/18390
AbstractThe heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. Such manipulations alter expressions of mechanosensitive genes which may anticipate induction of morphological changes in the developing heart. This paper aims to present different approaches for generating clinically relevant disturbed hemodynamics conditions using this embryonic chick model and to summarize identified mechanosensitive genes using the model, providing insights into embryonic origins of congenital heart defects.
SponsorQatar National Research Fund
Languageen
PublisherMDPI
Subjectchemical treatment
chick embryo
gene expression
hemodynamics
left atrial ligation
mechanobiology
mechanosensitive pathways
outflow tract banding
surgical interferences
vitelline vein ligation
TitleMechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.
TypeArticle
Issue Number4
Volume Number8
dc.accessType Full Text


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