Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.
Author | Alser, Maha |
Author | Shurbaji, Samar |
Author | Yalcin, Huseyin C |
Available date | 2021-04-29T09:35:04Z |
Publication Date | 2021-03-01 |
Publication Name | Journal of Cardiovascular Development and Disease |
Identifier | http://dx.doi.org/10.3390/jcdd8040032 |
Citation | Alser, M.; Shurbaji, S.; Yalcin, H.C. Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies. J. Cardiovasc. Dev. Dis. 2021, 8, 32. https://doi.org/10.3390/jcdd8040032 |
Abstract | The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. Such manipulations alter expressions of mechanosensitive genes which may anticipate induction of morphological changes in the developing heart. This paper aims to present different approaches for generating clinically relevant disturbed hemodynamics conditions using this embryonic chick model and to summarize identified mechanosensitive genes using the model, providing insights into embryonic origins of congenital heart defects. |
Sponsor | Qatar National Research Fund |
Language | en |
Publisher | MDPI |
Subject | chemical treatment chick embryo gene expression hemodynamics left atrial ligation mechanobiology mechanosensitive pathways outflow tract banding surgical interferences vitelline vein ligation |
Type | Article |
Issue Number | 4 |
Volume Number | 8 |
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