عرض بسيط للتسجيلة

المؤلفKumar, S. Udhaya
المؤلفPriya, N. Madhana
المؤلفNithya, S. R.
المؤلفKannan, Priyanka
المؤلفJain, Nikita
المؤلفKumar, D. Thirumal
المؤلفMagesh, R.
المؤلفYounes, Salma
المؤلفZayed, Hatem
المؤلفDoss, C. George Priya
تاريخ الإتاحة2021-06-22T04:36:07Z
تاريخ النشر2021-04-01
اسم المنشور3 Biotech
المعرّفhttp://dx.doi.org/10.1007/s13205-021-02749-0
الاقتباسKumar, S.U., Priya, N.M., Nithya, S.R. et al. A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing. 3 Biotech 11, 198 (2021). https://doi.org/10.1007/s13205-021-02749-0
الرقم المعياري الدولي للكتاب2190-572X
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103584293&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/20799
الملخصCoronavirus disease (COVID-19) pandemic is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of March 13, 2021, more than 118.9 million cases were infected with COVID-19 worldwide. SARS-CoV-2 is a positive-sense single-stranded RNA beta-CoV. Most COVID-19 infected individuals recover within 1–3 weeks. Nevertheless, approximately 5% of patients develop acute respiratory distress syndrome and other systemic complications, leading to death. Structural genetic analyses of SARS-CoV-2 have shown genomic resemblances but a low evolutionary correlation to SARS-CoV-1 responsible for the 2002–2004 outbreak. The S glycoprotein is critical for cell adhesion and the entrance of the virus into the host. The process of cell entry uses the cellular receptor named angiotensin-converting enzyme 2. Recent evidence proposed that the CD147 as a SARS-CoV-2′s potential receptor. The viral genome is mainly held by two non-structural proteins (NSPs), ORF1a and ORF1ab, along with structural proteins. Although NSPs are conserved among the βCoVs, mutations in NSP2 and NSP3 may play critical roles in transmitting the virus and cell tropism. To date, no specific/targeted anti-viral treatments exist. Notably, more than 50 COVID-19 candidate vaccines in clinical trials, and a few being administered. Preventive precautions are the primary strategy to limit the viral load transmission and spread, emphasizing the urgent need for developing significant drug targets and vaccines against COVID-19. This review provides a cumulative overview of the genomic structure, transmission, phylogeny of SARS-CoV-2 from Indian clusters, treatment options, updated discoveries, and future standpoints for COVID-19.
اللغةen
الناشرSpringer Verlag
الموضوعCOVID-19
COVID-19 molecular diagnosis
COVID-19 therapeutics
Drug repurposing
Hydroxychloroquine
India
Protease
Remdesivir
SARS-CoV-2
SARS-CoV-2 genome
Vaccines
العنوانA review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing
النوعArticle Review
رقم العدد4
رقم المجلد11
ESSN2190-5738
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة