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AuthorZhang, Haijun
AuthorDeng, Wei
AuthorWang, Xiangfei
AuthorWang, Shenguo
AuthorGe, Junbo
AuthorToft, Egon
Available date2021-07-05T11:03:40Z
Publication Date2016
Publication NameCatheterization and Cardiovascular Interventions
ResourceScopus
URIhttp://dx.doi.org/10.1002/ccd.25335
URIhttp://hdl.handle.net/10576/21170
AbstractObjectives To compare a new stent with an asymmetric coating, eluting the drug to the abluminal surface, to a stent with a conventional coating eluting the drug both to the luminal and the abluminal side. Background Stents with asymmetric coating, eluting the drug to the vessel wall (BPSES-A), could potentially give faster reendothelialization after percutaneous coronary interventions (PCI) and decrease in in-stent thrombosis and late restenosis. Methods BPSES-A, conventional coated stents (BPSES-C), biodegradable polymer stents without drug (BPS, for control), and bare metal stents (BMS, for control) were implanted into the coronary arteries of 38 pigs (75 stents). Pigs were sacrificed after 4, 12, and 24 weeks. Quantitative coronary angiography was used to compare in-stent late lumen loss (LLL) and electron microscopy was used to reveal levels of reendothelialization. Results The stents were all successfully implanted. LLL of BPSES-A, BPSES-C, BMS, and BPS were 0.56 ± 0.51, 0.60 ± 0.58, 0.89 ± 0.43, and 1.68 ± 0.30 mm, respectively, after 4 weeks. LLL of BPSES-A and BPSES-C were 0.63 ± 0.53 and 0.69 ± 0.24 mm, respectively, after 12 weeks. LLL of BPSES-A, BPSES-C, and BMS were 0.42 ± 0.15 m, 0.56 ± 0.28 mm, and 0.99 ± 0.13 mm, respectively, after 24 weeks. The scaling of reendothelialization was as follows: after 4 weeks BMS > = BPS > BPSES-A > BPSES-C, after 12 weeks BPSES-A > BPSES-C, and after 24 weeks BMS > BPSES-A > BPSES-C. Reendothelialization was better in BPSES-A than BPSES-C (P < 0.05). There was no correlation between LLL and reendothelialization (P = 0.42).
Languageen
PublisherJohn Wiley and Sons Inc.
Subjectabluminal drug elution
animal experiment
biodegradable polymer
coronary arteries
drug eluting stent
sirolimus
TitleSolely abluminal drug release from coronary stents could possibly improve reendothelialization
TypeArticle
PaginationE59-E66
Issue Number3
Volume Number88
dc.accessType Abstract Only


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