عرض بسيط للتسجيلة

المؤلفEl-Menyar, Ayman
المؤلفRizk, Nasser M.
المؤلفAsim, Mohammad
المؤلفAl-Thani, Hassan
المؤلفElgendy, Akram
المؤلفAl-Suwaidi, Jassim
تاريخ الإتاحة2021-07-05T11:03:40Z
تاريخ النشر2016
اسم المنشورAngiology
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1177/0003319715618039
معرّف المصادر الموحدhttp://hdl.handle.net/10576/21171
الملخصWe evaluated the association between beta-adrenergic receptor genes (ADRB1 and ADRB2) polymorphism, cardiovascular risk, and acute coronary syndrome (ACS) in individuals from an Arab ethnicity. A total of 388 Qatari participants were assessed and genotyped for ADRB1 (rs1801252 & rs1801253) and ADRB2 (rs1042718 & rs1042713) polymorphisms using allele-specific PCR. Minor allele frequencies (MAF) in each single-nucleotide polymorphisms (SNPs) did not show statistically significant difference between cases and controls. A higher proportion of patients with ACS had homozygous minor alleles (GG) for rs1801253 (28.8% vs 17.1%; P =.019) compared with controls. Among cases with ACS, there was an association of minor allele frequency (G) for rs1801253 with severe coronary artery stenosis (0.485 vs 0.428; P =.04) than that of insignificant stenosis (<50% stenosis). There was a 3-fold increased risk of significant coronary stenosis in patients with diabetes mellitus (DM) and carrier of rs1801253 genotypes with dominant model (P =.01) and recessive model (P =.05). There is a possible synergic association between DM, carrier of ADRB1 (Arg389Gly) variants, and significant coronary artery stenosis among Arabs. Further prospective studies with larger sample sizes are warranted to support our findings. The Author(s) 2015.
اللغةen
الناشرSAGE Publications Inc.
الموضوعArab
beta receptors
coronary artery disease
diabetes
genotypes
polymorphism
العنوانAssociation of β-Adrenergic Receptor Gene Polymorphisms With Acute Coronary Syndrome and Cardiovascular Risk Factors in an Arab Population
النوعArticle
الصفحات762-771
رقم العدد8
رقم المجلد67
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة