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AuthorEl-Menyar, Ayman
AuthorRizk, Nasser M.
AuthorAsim, Mohammad
AuthorAl-Thani, Hassan
AuthorElgendy, Akram
AuthorAl-Suwaidi, Jassim
Available date2021-07-05T11:03:40Z
Publication Date2016
Publication NameAngiology
ResourceScopus
URIhttp://dx.doi.org/10.1177/0003319715618039
URIhttp://hdl.handle.net/10576/21171
AbstractWe evaluated the association between beta-adrenergic receptor genes (ADRB1 and ADRB2) polymorphism, cardiovascular risk, and acute coronary syndrome (ACS) in individuals from an Arab ethnicity. A total of 388 Qatari participants were assessed and genotyped for ADRB1 (rs1801252 & rs1801253) and ADRB2 (rs1042718 & rs1042713) polymorphisms using allele-specific PCR. Minor allele frequencies (MAF) in each single-nucleotide polymorphisms (SNPs) did not show statistically significant difference between cases and controls. A higher proportion of patients with ACS had homozygous minor alleles (GG) for rs1801253 (28.8% vs 17.1%; P =.019) compared with controls. Among cases with ACS, there was an association of minor allele frequency (G) for rs1801253 with severe coronary artery stenosis (0.485 vs 0.428; P =.04) than that of insignificant stenosis (<50% stenosis). There was a 3-fold increased risk of significant coronary stenosis in patients with diabetes mellitus (DM) and carrier of rs1801253 genotypes with dominant model (P =.01) and recessive model (P =.05). There is a possible synergic association between DM, carrier of ADRB1 (Arg389Gly) variants, and significant coronary artery stenosis among Arabs. Further prospective studies with larger sample sizes are warranted to support our findings. The Author(s) 2015.
Languageen
PublisherSAGE Publications Inc.
SubjectArab
beta receptors
coronary artery disease
diabetes
genotypes
polymorphism
TitleAssociation of β-Adrenergic Receptor Gene Polymorphisms With Acute Coronary Syndrome and Cardiovascular Risk Factors in an Arab Population
TypeArticle
Pagination762-771
Issue Number8
Volume Number67
dc.accessType Abstract Only


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