عرض بسيط للتسجيلة

المؤلفSellami, Maha
المؤلفAl-Muraikhy, Shamma
المؤلفAl-Jaber, Hend
المؤلفAl-Amri, Hadaia
المؤلفAl-Mansoori, Layla
المؤلفMazloum, Nayef A.
المؤلفDonati, Francesco
المؤلفBotre, Francesco
المؤلفElrayess, Mohamed A.
تاريخ الإتاحة2021-07-07T04:35:01Z
تاريخ النشر2021-07-01
اسم المنشورAntioxidants
المعرّفhttp://dx.doi.org/10.3390/antiox10071035
الاقتباسSellami, M.; Al-muraikhy, S.; Al-Jaber, H.; Al-Amri, H.; Al-Mansoori, L.; Mazloum, N.A.; Donati, F.; Botre, F.; Elrayess, M.A. Age and Sport Intensity-Dependent Changes in Cytokines and Telomere Length in Elite Athletes. Antioxidants 2021, 10, 1035. https://doi.org/10.3390/antiox10071035
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108686927&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/21325
الملخصBackground: Exercise-associated immune response plays a crucial role in the aging process. The aim of this study is to investigate the effect of sport intensity on cytokine levels, oxidative stress markers and telomere length in aging elite athletes. Methods: In this study, 80 blood samples from consenting elite athletes were collected for anti-doping analysis at an anti-doping laboratory in Italy (FMSI). Participants were divided into three groups according to their sport intensity: low-intensity skills and power sports (LI, n = 18); moderate-intensity mixed soccer players (MI, n = 31); and high-intensity endurance sports (HI, n = 31). Participants were also divided into two age groups: less than 25 (n = 45) and above 25 years old (n = 35). Serum levels of 10 pro and anti-inflammatory cytokines and two antioxidant enzymes were compared in age and sport intensity groups and telomere lengths were measured in their respective blood samples. Results: Tumor necrosis factor-alpha (TNF-α) was the only cytokine showing significantly higher concentration in older athletes, regardless of sport intensity. Interleukin (IL)-10 increased significantly in HI regardless of age group, whereas IL-6 concentration was higher in the older HI athletes. IL-8 showed a significant interaction with sport intensity in different age groups. Overall, significant positive correlations among levels of IL-6, IL-10, IL-8 and TNF-α were identified. The antioxidant catalase activity was positively correlated with levels of TNF-α. Telomere length increased significantly with sport intensity, especially in the younger group. Conclusion: HI had longer telomeres and higher levels of pro-and anti-inflammatory cytokines, suggesting less aging in HI compared to low and moderate counterparts in association with heightened immune response. Investigation of the functional significance of these associations on the health and performance of elite athletes is warranted.
اللغةen
الناشرMDPI
الموضوعAging
Anti-inflammatory cytokines
Elite athletes
Pro-inflammatory cytokines
Sport intensity
Telomere length
العنوانAge and sport intensity-dependent changes in cytokines and telomere length in elite athletes
النوعArticle Review
رقم العدد7
رقم المجلد10
ESSN2076-3921
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة