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AuthorYalcin, Huseyin C.
AuthorSukumaran, Vijayakumar
AuthorAl-Ruweidi, Mahmoud Khatib A.A.
AuthorShurbaji, Samar
Available date2021-07-07T05:36:22Z
Publication Date2021-07-01
Publication NameInternational Journal of Molecular Sciences
Identifierhttp://dx.doi.org/10.3390/ijms22136703
CitationYalcin, H.C.; Sukumaran, V.; Al-Ruweidi, M.K.A.A.; Shurbaji, S. Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms. Int. J. Mol. Sci. 2021, 22, 6703. https://doi.org/10.3390/ijms22136703
ISSN16616596
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108201510&origin=inward
URIhttp://hdl.handle.net/10576/21329
AbstractThe SARS-CoV-2 virus utilizes angiotensin converting enzyme (ACE-2) for cell entry and infection. This enzyme has important functions in the renin-angiotensin aldosterone system to preserve cardiovascular function. In addition to the heart, it is expressed in many tissues including the lung, intestines, brain, and kidney, however, its functions in these organs are mostly unknown. ACE-2 has membrane-bound and soluble forms. Its expression levels are altered in disease states and by a variety of medications. Currently, it is not clear how altered ACE-2 levels influence ACE-2 virulence and relevant complications. In addition, membrane-bound and soluble forms are thought to have different effects. Most work on this topic in the literature is on the SARS-CoV virus that has a high genetic resemblance to SARS-Co-V-2 and also uses ACE-2 enzyme to enter the cell, but with much lower affinity. More recent studies on SARS-CoV-2 are mainly clinical studies aiming at relating the effect of medications that are thought to influence ACE-2 levels, with COVID-19 outcomes for patients under these medications. This review paper aims to summarize what is known about the relationship between ACE-2 levels and SARS-CoV/SARS-CoV-2 virulence under altered ACE-2 expression states.
SponsorThe publication of this article was covered with a generous support from BARZAN HOLDINGS
Languageen
PublisherMDPI
SubjectACE inhibitors
ACE-2
Angiotensin receptor blockers
ARDS
COVID-19
RAAS
SARS-CoV
Shedding
TitleDo changes in ace-2 expression affect sars-cov-2 virulence and related complications: A closer look into membrane-bound and soluble forms
TypeArticle Review
Issue Number13
Volume Number22
ESSN1422-0067
ESSN1422-0067
dc.accessType Open Access


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