The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data
Date
2021-08-09Author
Kerkadi, AbdelhamidAlkudsi, Dana Samir
Hamad, Sara
Alkeldi, Hanan Mohamed
Salih, Reem
Agouni, Abdelali
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Metadata
Show full item recordAbstract
Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular
diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional distur bances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn)
and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the
association between CMR factors and the status of Zn and Cu, in addition to Zn/Cu ratio. A total
of 575 Qatari men and women aged 18 years and older were obtained from Qatar Biobank. Plasma
levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS).
Anthropometric data and CMR factors were determined using standard methods. Adjusted associa tions between trace minerals and CMR were estimated by logistic regression. Partial correlation was
performed to test the strength of the associations. Zn was not strongly correlated (p-value > 0.01)
or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated
positively with body mass index (BMI) (0.23; p < 0.001), pulse rate (PR) (0.18; p < 0.001), total
cholesterol (0.13; p = 0.01), and high-density lipoproteins (HDL) (0.27; p < 0.001); and negatively with
diastolic blood pressure (DBP) (−0.13; p = 0.01). High plasma Cu significantly decreased the risk of
metabolic syndrome (MetS) (0.121; p < 0.001). Furthermore, Zn/Cu ratio positively correlated with
waist circumference (0.13; p = 0.01), systolic blood pressure (0.13; p < 0.01), and DBP (0.14; p < 0.01);
and negatively with BMI (−0.19; p < 0.001), PR (−0.17; p < 0.001), and HDL (−0.27; p < 0.001). High
Zn/Cu ratio increased the prevalence of low HDL (4.508; p < 0.001) and MetS (5.570; p < 0.01). These
findings suggest that high plasma Cu levels are associated with a protective effect on DBP, HDL and
MetS and that high plasma Zn/Cu ratio is associated with the risk of having low HDL and MetS.
DOI/handle
http://hdl.handle.net/10576/22649Collections
- Human Nutrition [371 items ]