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AuthorWilby, Kyle John
AuthorShabana, Sara
AuthorEnsom, Mary H.H.
AuthorMarra, Fawziah
Available date2021-09-05T05:40:20Z
Publication Date2016
Publication NameClinical Pharmacokinetics
ResourceScopus
ISSN3125963
URIhttp://dx.doi.org/10.1007/s40262-015-0303-1
URIhttp://hdl.handle.net/10576/22734
AbstractTuberculosis is a leading cause of infectious disease-related morbidity and mortality worldwide. Additionally, treatment is complex with most patients requiring combination therapy of first-line agents for multiple months. Children are especially at risk from the medications used to treat tuberculosis and therefore interventions to optimize both efficacy and safety are needed. Protocols exist for therapeutic drug monitoring in tuberculosis patients yet there is a gap in knowledge regarding the extent of any benefits achieved, especially in children. This review aims to summarize and evaluate literature reporting outcomes related to the measurement of drug concentrations of first-line agents used to treat tuberculosis (rifampin, isoniazid, pyrazinamide, ethambutol) in children. Findings showed a lack of strong evidence to support therapeutic drug monitoring in children with tuberculosis. Standard weight-based dosing of first-line agents does not commonly achieve target concentrations yet the effect on clinical outcomes remains unclear. As such, therapeutic drug monitoring should not be recommended currently as a widespread practice for all children with tuberculosis. However, future research should assess any benefit in special populations such as those with relapsing or recurrent disease, or those presenting with adverse drug reactions. 2015, Springer International Publishing Switzerland.
Languageen
PublisherSpringer International Publishing
Subjectethambutol
isoniazid
pyrazinamide
rifampicin
tuberculostatic agent
child
clinical decision making
clinical practice
drug blood level
drug efficacy
drug monitoring
drug safety
evidence based medicine
human
maximum plasma concentration
practice guideline
priority journal
Review
systematic review
tuberculosis
dose calculation
dose response
procedures
tuberculosis
Antitubercular Agents
Child
Dose-Response Relationship, Drug
Drug Dosage Calculations
Drug Monitoring
Humans
Tuberculosis
TitleA Critical Review of the Current Evidence for Measuring Drug Concentrations of First-Line Agents Used to Treat Tuberculosis in Children
TypeArticle Review
Pagination17-31
Issue Number1
Volume Number55
dc.accessType Abstract Only


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