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المؤلفGhosh, S.
المؤلفDas, Pj
المؤلفAvila, F.
المؤلفThwaits, Bk
المؤلفChowdhary, B., Raudsepp, T.
تاريخ الإتاحة2021-09-08T06:49:48Z
تاريخ النشر2016
اسم المنشورReproduction in Domestic Animals
المصدرScopus
الرقم المعياري الدولي للكتاب9366768
معرّف المصادر الموحدhttp://dx.doi.org/10.1111/rda.12636
معرّف المصادر الموحدhttp://hdl.handle.net/10576/22942
الملخصContents: Balanced autosomal translocations are a known cause for repeated early embryonic loss (REEL) in horses. In most cases, carriers of such translocations are phenotypically normal, but the chromosomal aberration negatively affects gametogenesis giving rise to both genetically balanced and unbalanced gametes. The latter, if involved in fertilization, result in REEL, whereas gametes with the balanced form of translocation will pass the defect into next generation. Therefore, in order to reduce the incidence of REEL, identification of translocation carriers is critical. Here, we report about a phenotypically normal 3-year-old Arabian mare that had repeated resorption of conceptuses prior to day 45 of gestation and was diagnosed with REEL. Conventional and molecular cytogenetic analyses revealed that the mare had normal chromosome number 64,XX but carried a non-mosaic and non-reciprocal autosomal translocation t(4;10)(q21;p15). This is a novel translocation described in horses with REEL and the first such report in Arabians. Previous cases of REEL due to autosomal translocations have exclusively involved Thoroughbreds. The findings underscore the importance of routine cytogenetic screening of breeding animals. 2016 Blackwell Verlag GmbH.
اللغةen
الناشرBlackwell Publishing Ltd
الموضوعanimal
case report
female
fluorescence in situ hybridization
gene translocation
genetics
horse
horse disease
karyotyping
pregnancy
recurrent abortion
veterinary
veterinary abortion
Abortion, Habitual
Abortion, Veterinary
Animals
Female
Horse Diseases
Horses
In Situ Hybridization, Fluorescence
Karyotyping
Pregnancy
Translocation, Genetic
العنوانA Non-Reciprocal Autosomal Translocation 64,XX, t(4;10)(q21;p15) in an Arabian Mare with Repeated Early Embryonic Loss
النوعArticle
الصفحات171-174
رقم العدد1
رقم المجلد51
dc.accessType Abstract Only


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