Show simple item record

AuthorShurbaji, Samar
AuthorManaph, Nimshitha P. Abdul
AuthorLtaief, Samia M.
AuthorAl-Shammari, Abeer R.
AuthorElzatahry, Ahmed
AuthorYalcin, Huseyin C.
Available date2021-09-21T09:59:31Z
Publication Date2021-09-08
Publication NameFrontiers in Nanotechnology
Identifierhttp://dx.doi.org/10.3389/fnano.2021.689718
CitationShurbaji S, Manaph NPA, Ltaief SM, Al-Shammari AR, Elzatahry A and Yalcin HC (2021) Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions. Front. Nanotechnol. 3:689718. doi: 10.3389/fnano.2021.689718
Identifier689718
URIhttp://hdl.handle.net/10576/23261
AbstractA growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer photothermal therapy. To be most effective, photothermal agents need to be internalized by the cancer cells. In this study, MXene was fabricated using chemical reactions and tested as a photothermal agent on MDA-231 breast cancer cells under static and physiological conditions. Fluid shear stress (∼0.1 Dyn/cm2) was applied using a perfusion system to mimic the physiological tumor microenvironment. The uptake of MXene was analyzed under fluid flow compared to static culture using confocal microscopy, scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and transmission electron microscopy (TEM). Furthermore, a viability assay was used to assess cell’s survival after exposing the treated cells to photothermal laser at different power densities and durations. We showed that when incubated with cancer cells, 2D MXene nanoparticles were successfully internalized into the cells resulting in increased intracellular temperatures when exposed to NIR laser. Interestingly, dynamic culture alone did not result in a significant increase in uptake suggesting the need for surface modifications for enhanced cellular uptake under shear stress.
SponsorQatar University
Languageen
PublisherFrontiers Media
SubjectCancer
photothermal therapy
static
dynamic
MXene
TitleCharacterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
TypeArticle
Volume Number3
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record