• English
    • العربية
  • العربية
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Help
    • Item Submission
    • Publisher policies
    • User guides
    • FAQs
  • About QSpace
    • Vision & Mission
View Item 
  •   Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Research Units
  • Biomedical Research Center
  • Biomedical Research Center Research
  • View Item
  • Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Research Units
  • Biomedical Research Center
  • Biomedical Research Center Research
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Investigation of the effect of anticoagulant usage in the flow diverter stent treatment of the patient-specific cerebral aneurysm using the Lagrangian coherent structures

    Thumbnail
    View/Open
    Publisher version (You have accessOpen AccessIcon)
    Publisher version (Check access options)
    Check access options
    Onur Mutlu - JClinNeuroSci.pdf (2.778Mb)
    Date
    2021-12-31
    Author
    Muhammed Furkan, Tercanlı
    Olcay, Ali Bahadır
    Mutlu, Onur
    Bilgin, Cem
    Hakyemez, Bahattin
    Metadata
    Show full item record
    Abstract
    Anticoagulants are prescribed to the flow diverter treated patients to diminish the risk of embolism in the arteries. In the present study, digital subtraction angiography images of a 49-year-old female patient with a left paraophthalmic aneurysm were used to build a numerical model to investigate the effect of an anticoagulant on hemodynamics at the aneurysm site. The Carreau-Yasuda viscosity model was utilized to define blood viscosity, and the coefficients of the viscosity model were updated based on the usage of warfarin. The five-cardiac cycle-long numerical simulations were performed, and Lagrangian coherent structures, hyperbolic time, and fluid particle analyses were also employed in the numerical models. These analyses allowed us to evaluate the formation of stagnated regions, recirculation zones, and the number of jailed particles inside the aneurysm sac following a flow diverter placement. It is realized that anticoagulant use caused blood to be less viscous, yielding a substantial amount of incoming blood flow to enter the aneurysm sac. Only 12% of the nearly 25,000 fluid particles seeded from the artery inlet have stayed inside the sac. Furthermore, the deviation between warfarin added blood and normal blood flow becomes more extensive, with every heartbeat undermining the effectiveness of patient-specific CFD models when the use of anticoagulants is overlooked in the viscosity models.
    URI
    https://www.sciencedirect.com/science/article/pii/S0967586821005142
    DOI/handle
    http://dx.doi.org/10.1016/j.jocn.2021.10.007
    http://hdl.handle.net/10576/24632
    Collections
    • Biomedical Research Center Research [‎785‎ items ]

    entitlement


    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of Digital Hub
      Communities & Collections Publication Date Author Title Subject Type Language Publisher
    This Collection
      Publication Date Author Title Subject Type Language Publisher

    My Account

    Login

    Statistics

    View Usage Statistics

    About QSpace

    Vision & Mission

    Help

    Item Submission Publisher policiesUser guides FAQs

    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Video