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AuthorAl-Shamasi, Al-Anood
AuthorElkaffash, Rozina
AuthorMohamed, Meram
AuthorRayan, Menatallah
AuthorAl-Khater, Dhabya
AuthorGadeau, Alain-Pierre
AuthorAhmed, Rashid
AuthorHasan, Anwarul
AuthorEldassouki, Hussein
AuthorYalcin, Huseyin Cagatay
AuthorAbdul-Ghani, Muhammad
AuthorMraiche, Fatima
Available date2021-11-29T11:05:37Z
Publication Date2021-11-24
Publication NameInternational Journal of Molecular Sciences
Identifierhttp://dx.doi.org/10.3390/ijms222312677
CitationAl-Shamasi, A.-A.; Elkaffash, R.; Mohamed, M.; Rayan, M.; Al-Khater, D.; Gadeau, A.-P.; Ahmed, R.; Hasan, A.; Eldassouki, H.; Yalcin, H.C.; Abdul-Ghani, M.; Mraiche, F. Crosstalk between Sodium–Glucose Cotransporter Inhibitors and Sodium–Hydrogen Exchanger 1 and 3 in Cardiometabolic Diseases. Int. J. Mol. Sci. 2021, 22, 12677. https://doi.org/10.3390/ijms222312677
Identifier12677
URIhttp://hdl.handle.net/10576/25190
AbstractAbnormality in glucose homeostasis due to hyperglycemia or insulin resistance is the hallmark of type 2 diabetes mellitus (T2DM). These metabolic abnormalities in T2DM lead to cellular dysfunction and the development of diabetic cardiomyopathy leading to heart failure. New antihyperglycemic agents including glucagon-like peptide-1 receptor agonists and the sodium–glucose cotransporter-2 inhibitors (SGLT2i) have been shown to attenuate endothelial dysfunction at the cellular level. In addition, they improved cardiovascular safety by exhibiting cardioprotective effects. The mechanism by which these drugs exert their cardioprotective effects is unknown, although recent studies have shown that cardiovascular homeostasis occurs through the interplay of the sodium–hydrogen exchangers (NHE), specifically NHE1 and NHE3, with SGLT2i. Another theoretical explanation for the cardioprotective effects of SGLT2i is through natriuresis by the kidney. This theory highlights the possible involvement of renal NHE transporters in the management of heart failure. This review outlines the possible mechanisms responsible for causing diabetic cardiomyopathy and discusses the interaction between NHE and SGLT2i in cardiovascular diseases.
SponsorQatar University
Languageen
PublisherMDPI
Subjectsodium–glucose cotransporter inhibitors
SGLT1
SGLT2
sodium–hydrogen exchanger
NHE1
NHE3
cardiovascular diseases
diabetes
TitleCrosstalk between Sodium–Glucose Cotransporter Inhibitors and Sodium–Hydrogen Exchanger 1 and 3 in Cardiometabolic Diseases
TypeArticle
Issue Number23
Volume Number22
dc.accessType Open Access


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