Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells
Author | Hassani, Abdelkader |
Author | Hussain, Siti Aslina |
Author | Al-Qubaisi, Mothanna Sadiq |
Author | Belfar, Mohamed Lakhder |
Author | Belkhalfa, Hakim |
Author | Enezei, Hamid Hammad |
Author | Zentou, Hamid |
Author | Ibrahim, Wisam Nabeel |
Author | Doolaanea, Abd Almonem |
Available date | 2021-12-23T09:04:02Z |
Publication Date | 2022-01-01 |
Publication Name | Biocell |
Identifier | http://dx.doi.org/10.32604/biocell.2022.016848 |
Citation | HASSANI, A., HUSSAIN, S. A., AL-QUBAISI, M. S., BELFAR, M. L., BELKHALFA, H. et al. (2022). Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells. BIOCELL, 46(3), 677–687. |
ISSN | 03279545 |
Abstract | The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension. |
Language | en |
Publisher | Tech Science Press |
Subject | Antioxidants Cancer cells Curcumin Gum arabic Nanoparticles |
Type | Article |
Pagination | 677-687 |
Issue Number | 3 |
Volume Number | 46 |
ESSN | 1667-5746 |
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Biomedical Sciences [697 items ]