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AuthorUra, Blendi
AuthorCelsi, Fulvio
AuthorZupin, Luisa
AuthorArrigoni, Giorgio
AuthorBattisti, Ilaria
AuthorGaita, Bartolomea
AuthorGrasso, Domenico Leonardo
AuthorOrzan, Eva
AuthorSagredini, Raffaella
AuthorBarbi, Egidio
AuthorCrovella, Sergio
Available date2022-01-24T06:35:25Z
Publication Date2020-12-01
Publication NameInternational Journal of Molecular Sciences
Identifierhttp://dx.doi.org/10.3390/ijms21239291
CitationUra, B.; Celsi, F.; Zupin, L.; Arrigoni, G.; Battisti, I.; Gaita, B.; Grasso, D.L.; Orzan, E.; Sagredini, R.; Barbi, E.; Crovella, S. Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media. Int. J. Mol. Sci. 2020, 21, 9291. https://doi.org/10.3390/ijms21239291
ISSN16616596
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097442615&origin=inward
URIhttp://hdl.handle.net/10576/25840
AbstractRecurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the context of pediatric otolaryngology is adenotonsillar hypertrophy (ATH), a common cause of obstructive sleep apnea syndrome. Aimed at unraveling the differential modulation of proteins in the two pathologies and at understanding the possible pathways involved in their onset, we analyzed the proteomic profile of the adenoids from 14 RAOM and ATH patients by using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). The 2-DE coupled with MS allowed us to identify 23 spots with significant (p-value < 0.05) changes in protein amount, recognizing proteins involved in neutrophil degranulation and glycolysis pathways.
SponsorThis research was funded by I.R.C.C.S. “B. G.”, grant number RC 02/20 and RC 15/17.
Languageen
PublisherMDPI
Subject2-DE
Adenotonsillar hypertrophy
Proteomics
Recurrent otitis
TitleProteomic study identifies glycolytic and inflammation pathways involved in recurrent otitis media
TypeArticle
Issue Number23
Volume Number21
ESSN1422-0067
dc.accessType Open Access


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