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AuthorAl-Zaqri, Nabil
AuthorSalih, Kifah S.M.
AuthorAwwadi, Firas F.
AuthorAlsalme, Ali
AuthorAlharthi, Fahad A.
AuthorAlsyahi, Amjad
AuthorAli, Anas Al
AuthorZarrouk, Abdelkader
AuthorAljohani, Meshari
AuthorChetouni, Ahmed
AuthorWarad, Ismail
Available date2022-01-25T10:33:29Z
Publication Date2020-01-01
Publication NameJournal of Coordination Chemistry
Identifierhttp://dx.doi.org/10.1080/00958972.2020.1841898
CitationNabil Al-Zaqri, Kifah S. M. Salih, Firas F. Awwadi, Ali Alsalme, Fahad A. Alharthi, Amjad Alsyahi, Anas Al Ali, Abdelkader Zarrouk, Meshari Aljohani, Ahmed Chetouni & Ismail Warad (2020) Synthesis, physicochemical, thermal, and XRD/HSA interactions of mixed [Cu(Bipy)(Dipn)](X)2 complexes: DNA binding and molecular docking evaluation, Journal of Coordination Chemistry, 73:23, 3236-3248, DOI: 10.1080/00958972.2020.1841898
ISSN00958972
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095733187&origin=inward
URIhttp://hdl.handle.net/10576/25935
AbstractTwo water-soluble dicationic complexes, [Cu(bipy)(dipn)](BF4)2 (1) and [Cu(bipy)(dipn)](NO3)2 (2) (bipy = 2.2-bipyridine and dipn = dipropylenetriamine), were synthesized in high yields. The desired complexes were characterized by CHN-EA, UV–Vis, SEM, EDS, FT-IR, TGA, and XRD. The single-crystal XRD of [Cu(bipy)(dipn)](BF4)2 reflected that Cu(II) complex is formed in a distorted square pyramid configuration. The Hirshfeld surface analysis (HSA) confirmed more powerful atom–atom interaction, the hydrogen bonding in H…F, supporting the outcome of XRD. The influences of the CT-DNA/complexes were gathered by viscosity, CV, and electronic absorption measurements. The estimated binding constants (Kb) for 1 and 2 were 4.5 × 104 and 3.4 × 104 M−1, respectively. Complex 2 revealed slightly poorer DNA binding capability than 1. Eventually, the molecular docking of [Cu(bipy)(dipn)]+2 species was evaluated and demonstrated employing 1BNA-DNA segment.
SponsorThe authors appreciate the Deanship of Scientific Research at King Saud University for funding this research work through grant # RG-1440-141.
Languageen
PublisherTaylor and Francis
Subject2.2-bipyridine
Cu(II) complexes
dipropylenetriamine
DNA binding
XRD
TitleSynthesis, physicochemical, thermal, and XRD/HSA interactions of mixed [Cu(Bipy)(Dipn)](X)2 complexes: DNA binding and molecular docking evaluation
TypeArticle
Pagination3236-3248
Issue Number23
Volume Number73
ESSN1029-0389
dc.accessType Full Text


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