The prevalence of adaptive immunity to COVID-19 and reinfection after recovery - a comprehensive systematic review and meta-analysis.
![Thumbnail](/bitstream/handle/10576/26898/The%20prevalence%20of%20adaptive%20immunity%20to%20COVID%2019%20and%20reinfection%20after%20recovery%20a%20comprehensive%20systematic%20review%20and%20meta%20analysis.pdf.jpg?sequence=4&isAllowed=y)
عرض / فتح
التاريخ
2022-01-31المؤلف
Chivese, TawandaMatizanadzo, Joshua T
Musa, Omran A H
Hindy, George
Furuya-Kanamori, Luis
Islam, Nazmul
Al-Shebly, Rafal
Shalaby, Rana
Habibullah, Mohammad
Al-Marwani, Talal A
Hourani, Rizeq F
Nawaz, Ahmed D
Haider, Mohammad Z
Emara, Mohamed M
Cyprian, Farhan
Doi, Suhail A R
...show more authors ...show less authors
البيانات الوصفية
عرض كامل للتسجيلةالملخص
This study aims to estimate the prevalence and longevity of detectable SARS-CoV-2 antibodies and T and B memory cells after recovery. In addition, the prevalence of COVID-19 reinfection and the preventive efficacy of previous infection with SARS-CoV-2 were investigated. A synthesis of existing research was conducted. The Cochrane Library, the China Academic Journals Full Text Database, PubMed, and Scopus, and preprint servers were searched for studies conducted between 1 January 2020 to 1 April 2021. Included studies were assessed for methodological quality and pooled estimates of relevant outcomes were obtained in a meta-analysis using a bias adjusted synthesis method. Proportions were synthesized with the Freeman-Tukey double arcsine transformation and binary outcomes using the odds ratio (OR). Heterogeneity was assessed using the I and Cochran's Q statistics and publication bias was assessed using Doi plots. Fifty-four studies from 18 countries, with around 12,000,000 individuals, followed up to 8 months after recovery, were included. At 6-8 months after recovery, the prevalence of SARS-CoV-2 specific immunological memory remained high; IgG - 90.4% (95%CI 72.2-99.9, I = 89.0%), CD4+ - 91.7% (95%CI 78.2-97.1y), and memory B cells 80.6% (95%CI 65.0-90.2) and the pooled prevalence of reinfection was 0.2% (95%CI 0.0-0.7, I = 98.8). Individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection (OR 0.19, 95% CI 0.1-0.3, I = 90.5%). Around 90% of recovered individuals had evidence of immunological memory to SARS-CoV-2, at 6-8 months after recovery and had a low risk of reinfection.
المجموعات
- أبحاث فيروس كورونا المستجد (كوفيد-19) [801 items ]
- أبحاث الطب [1397 items ]