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AuthorChauhan, Ravi
AuthorBhat, Ajaz A
AuthorMasoodi, Tariq
AuthorBagga, Puneet
AuthorReddy, Ravinder
AuthorGupta, Ashna
AuthorSheikh, Zahoor Ahmad
AuthorMacha, Muzafar A
AuthorHaris, Mohammad
AuthorSingh, Mayank
Available date2022-02-24T09:31:55Z
Publication Date2021-11-10
Publication NameJournal of Experimental & Clinical Cancer Research
Identifierhttp://dx.doi.org/10.1186/s13046-021-02163-7
CitationChauhan, R., Bhat, A.A., Masoodi, T. et al. Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells. J Exp Clin Cancer Res 40, 356 (2021). https://doi.org/10.1186/s13046-021-02163-7
URIhttp://hdl.handle.net/10576/27399
AbstractProtein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to tumorigenesis. Ubiquitin-specific peptidases are attractive therapeutic targets in different cancers and are being evaluated for clinical development. Ubiquitin-specific peptidase 37 (USP37) is one of the least studied members of the USP family. USP37 controls numerous aspects of oncogenesis, including stabilizing many different oncoproteins. Recent work highlights the role of USP37 in stimulating the epithelial-mesenchymal transition and metastasis in lung and breast cancer by stabilizing SNAI1 and stimulating the sonic hedgehog pathway, respectively. Several aspects of USP37 biology in cancer cells are yet unclear and are an active area of research. This review emphasizes the importance of USP37 in cancer and how identifying its molecular targets and signalling networks in various cancer types can help advance cancer therapeutics.
SponsorThis study was supported by AIIMS Intramural grant (Grant number: A514) and AIIMS IITD Grant (AI-34) from All India Institute of Medical Sciences (AIIMS) New Delhi, Delhi India to Mayank singh. Sidra Medicine Precision Program provides research funding to Mohammad Haris (5081012002). Muzafar A. Macha is supported by Ramalingaswami Fellowship (Grant number: D.O. NO.BT/HRD/35/02/2006) from the Department of Biotechnology, Govt. of India, New Delhi.
Languageen
PublisherBMC
SubjectDeubiquitylating enzymes
Epithelial–mesenchymal transition
Oncogene
Ubiquitin
Ubiquitin-specific peptidase
Ubiquitin-specific peptidase 37
TitleUbiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells.
TypeArticle Review
Issue Number1
Volume Number40
ESSN1756-9966
dc.accessType Open Access


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