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المؤلفKirti.S., Prabhu
المؤلفBhat, Ajaz A.
المؤلفSiveen, Kodappully S.
المؤلفKuttikrishnan, Shilpa
المؤلفRaza, Syed Shadab
المؤلفRaheed, Thesni
المؤلفJochebeth, Anh
المؤلفKhan, Abdul Q.
المؤلفChawdhery, M.Zafar
المؤلفHaris, Mohammad
المؤلفKulinski, Michal
المؤلفDermime, Said
المؤلفSteinhoff, Martin
المؤلفUddin, Shahab
تاريخ الإتاحة2022-02-27T05:17:45Z
تاريخ النشر2021-12-31
اسم المنشورBiomedicine & Pharmacotherapy
المعرّفhttp://dx.doi.org/10.1016/j.biopha.2021.112358
الاقتباسPrabhu, K. S., Bhat, A. A., Siveen, K. S., Kuttikrishnan, S., Raza, S. S., Raheed, T., ... & Uddin, S. (2021). Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway. Biomedicine & Pharmacotherapy, 144, 112358.
الرقم المعياري الدولي للكتاب07533322
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0753332221011422
معرّف المصادر الموحدhttp://hdl.handle.net/10576/27405
الملخصEffective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates the need for new therapeutic interventions with fewer side effects. Natural compounds offer various benefits such as easy access, minimal side effects, and multi-molecular targets and thus, can prove useful in treating lung cancer. Sanguinarine (SNG), a natural compound, possesses favorable therapeutic potential against a variety of cancers. Here, we examined the underlying molecular mechanisms of SNG in Non-Small Cell Lung Cancer (NSCLC) cells. SNG suppressed cell growth and induced apoptosis via downregulation of the constitutively active JAK/STAT pathway in all the NSCLC cell lines. siRNA silencing of STAT3 in NSCLC cells further confirmed the involvement of the JAK/STAT signaling cascade. SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. In addition, we established the antitumor effects of SNG through reactive oxygen species (ROS) production, as inhibiting ROS production prevented the apoptosis-inducing potential of SNG. In vivo xenograft tumor model further validated our in vitro findings. Overall, our study investigated the molecular mechanisms by which SNG induces apoptosis in NSCLC, providing avenues for developing novel natural compound-based cancer therapies.
اللغةen
الناشرElsevier
الموضوعApoptosis
Antiproliferative
Alkaloids
Antioxidants
Cancer stem cells
Sanguinarine
ROS
STAT3
العنوانSanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
النوعArticle
رقم المجلد144
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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