Show simple item record

AuthorKirti.S., Prabhu
AuthorBhat, Ajaz A.
AuthorSiveen, Kodappully S.
AuthorKuttikrishnan, Shilpa
AuthorRaza, Syed Shadab
AuthorRaheed, Thesni
AuthorJochebeth, Anh
AuthorKhan, Abdul Q.
AuthorChawdhery, M.Zafar
AuthorHaris, Mohammad
AuthorKulinski, Michal
AuthorDermime, Said
AuthorSteinhoff, Martin
AuthorUddin, Shahab
Available date2022-02-27T05:17:45Z
Publication Date2021-12-31
Publication NameBiomedicine & Pharmacotherapy
Identifierhttp://dx.doi.org/10.1016/j.biopha.2021.112358
CitationPrabhu, K. S., Bhat, A. A., Siveen, K. S., Kuttikrishnan, S., Raza, S. S., Raheed, T., ... & Uddin, S. (2021). Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway. Biomedicine & Pharmacotherapy, 144, 112358.
ISSN07533322
URIhttps://www.sciencedirect.com/science/article/pii/S0753332221011422
URIhttp://hdl.handle.net/10576/27405
AbstractEffective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates the need for new therapeutic interventions with fewer side effects. Natural compounds offer various benefits such as easy access, minimal side effects, and multi-molecular targets and thus, can prove useful in treating lung cancer. Sanguinarine (SNG), a natural compound, possesses favorable therapeutic potential against a variety of cancers. Here, we examined the underlying molecular mechanisms of SNG in Non-Small Cell Lung Cancer (NSCLC) cells. SNG suppressed cell growth and induced apoptosis via downregulation of the constitutively active JAK/STAT pathway in all the NSCLC cell lines. siRNA silencing of STAT3 in NSCLC cells further confirmed the involvement of the JAK/STAT signaling cascade. SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. In addition, we established the antitumor effects of SNG through reactive oxygen species (ROS) production, as inhibiting ROS production prevented the apoptosis-inducing potential of SNG. In vivo xenograft tumor model further validated our in vitro findings. Overall, our study investigated the molecular mechanisms by which SNG induces apoptosis in NSCLC, providing avenues for developing novel natural compound-based cancer therapies.
Languageen
PublisherElsevier
SubjectApoptosis
Antiproliferative
Alkaloids
Antioxidants
Cancer stem cells
Sanguinarine
ROS
STAT3
TitleSanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
TypeArticle
Volume Number144
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record