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AuthorDas, Sandra Concepcion
AuthorVaradharajan, Kavitha
AuthorShanmugakonar, Muralitharan
AuthorAl-Naemi, Hamda A.
Available date2022-02-27T08:29:30Z
Publication Date2021-08-10
Publication NameFrontiers in Pharmacology
Identifierhttp://dx.doi.org/10.3389/fphar.2021.663048
CitationDas SC, Varadharajan K, Shanmugakonar M and Al-Naemi HA (2021) Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat. Front. Pharmacol. 12:663048. doi: 10.3389/fphar.2021.663048
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85113360296&origin=inward
URIhttp://hdl.handle.net/10576/27438
AbstractThe aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl2 in drinking water for 10 weeks followed by withdrawal of cadmium treatment for 4 weeks. Following the completion of the treatment, gene expression of inflammatory mediators (IL-1β, IL-6, IL-10, TNF-α and NF-κB), protein expression of MMP-2, MMP-9 and their respective inhibitors- TIMP-1 and TIMP-2, and gelatinolytic activity of MMP-2 and MMP-9 were determined. At the protein level, cadmium incites a differential effect on the expression and activity of gelatinases and their endogenous inhibitors in an exposure-dependent manner. Results also show that the administered cadmium dose elicits an inflammatory response until week 10 that slightly diminishes after 4 weeks. This study provides evidence of cadmium-induced imbalance in the MMP-TIMP system in the cardiac tissue. This imbalance may be mediated by cadmium-induced inflammation that could contribute to various cardiovascular pathologies.
Languageen
PublisherFrontiers Media
Subjectcadmium
cardiac
inflammatory cytokines
MMP
TIMP
TitleChronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat
TypeArticle
Volume Number12
ESSN1663-9812
dc.accessType Full Text


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