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المؤلفGately, Fleur
المؤلفAli, Kamran
المؤلفBurns, Lorna
تاريخ الإتاحة2022-03-13T07:35:45Z
تاريخ النشر2022-01-01
اسم المنشورEvidence-Based Dentistry
المعرّفhttp://dx.doi.org/10.1038/s41432-021-0211-1
الاقتباسGately, F., Ali, K. & Burns, L. The effect of pre-emptive ibuprofen on post-operative pain after removal of lower third molar teeth: a systematic review. Evid Based Dent (2022). https://doi.org/10.1038/s41432-021-0211-1
الرقم المعياري الدولي للكتاب14620049
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85125647663&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/27995
الملخصObjective To investigate the effect of pre-emptive ibuprofen on post-operative pain after lower third molar surgery. Methods A search for randomised controlled trials was undertaken across the databases Medline, Embase, Cochrane Central and Dentistry and Oral Sciences Source. Citation searching was used to supplement the database search. Inclusion and exclusion criteria were used for independent double screening by two assessors. Results A total of five randomised controlled trials were included in the review. A risk of bias assessment identified some concerns in four of the included studies. One study was assessed as having low risk of bias. The important outcomes measured were post-operative pain intensity, total pain relief, use of rescue analgesia, time to rescue analgesia and total consumption of rescue analgesia. In two trials, pre-emptive ibuprofen was shown to significantly reduce pain intensity after lower third molar surgery compared with placebo. Two trials showed no significant difference between ibuprofen and placebo groups. Pre-emptive ibuprofen was shown to provide superior pain relief compared with placebo in the one trial measuring this outcome. Where the use of rescue medication was measured as an outcome, two trials showed that pre-emptive ibuprofen was superior to placebo, one trial showed that placebo was superior to ibuprofen and two trials found no significant difference between ibuprofen and placebo groups. Conclusion Due to the inconsistency of the results, there is insufficient evidence to support the use of pre-emptive ibuprofen for management of post-operative pain after lower third molar surgery. Further research into the effects of pre-emptive analgesia on the surgical pain pathway is required.
اللغةen
الناشرSpringer Nature
الموضوعibuprofen
lower third molar teeth
pre-emptive ibuprofen
العنوانThe effect of pre-emptive ibuprofen on post-operative pain after removal of lower third molar teeth: a systematic review
النوعArticle Review
ESSN1476-5446
dc.accessType Abstract Only


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