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AuthorRuzaid, Dania Adila Ahmad
AuthorMahat, Mohd Muzamir
AuthorShafiee, Saiful Arifin
AuthorSofian, Zarif Mohamed
AuthorSabere, Awis Sukarni Mohmad
AuthorRamli, Rosmamuhamadani
AuthorOsman, Hazwanee
AuthorHamzah, Hairul Hisham
AuthorAriffinm, Zaidah Zainal
AuthorSadasivuni, Kishor Kumar
Available date2022-03-23T06:35:45Z
Publication Date2021
Publication NamePolymers
ResourceScopus
Identifierhttp://dx.doi.org/10.3390/polym13193395
CitationAhmad Ruzaidi DA, Mahat MM, Shafiee SA, Mohamed Sofian Z, Mohmad Sabere AS, Ramli R, Osman H, Hamzah HH, Zainal Ariffin Z, Sadasivuni KK. Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review. Polymers. 2021; 13(19):3395. https://doi.org/10.3390/polym13193395
URIhttp://hdl.handle.net/10576/28561
AbstractScaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompatible and biodegradable, and must possess excellent functionality and bioactivity. The different polymers that are used in fabricating scaffolds can influence these parameters. Polysaccharide-based polymers, such as collagen and chitosan, exhibit exceptional biocompatibility and biodegradability, while the degradability of synthetic polymers can be improved using chemical modifications. However, these modifications require multiple steps of chemical reactions to be carried out, which could potentially compromise the end product?s biosafety. At present, conducting polymers, such as poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS), poly-aniline, and polypyrrole, are often incorporated into matrix scaffolds to produce electrically conductive scaffold composites. However, this will reduce the biodegradability rate of scaffolds and, therefore, agitate their biocompatibility. This article discusses the current trends in fabricating electrically conductive scaffolds, and provides some insight regarding how their immunogenicity performance can be interlinked with their physical and biodegradability properties.
SponsorThis work was carried by the NPRP grant # NPRP11S-1221-170116 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors. The authors wish to thank Norzawani Buang M Yassin, of Imperial College London, United Kingdom, for the useful discussion.
Languageen
PublisherMDPI
SubjectBiocompatibility
Biomedical application
Conducting polymer
Conductive scaffolds
Degradation rate
Fabrication of scaffolds
PEDOT: PSS
Tissue engineering
TitleAdvocating electrically conductive scaffolds with low immunogenicity for biomedical applications: A review
TypeArticle Review
Issue Number19
Volume Number13
dc.accessType Open Access


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