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AuthorSoliman, Alaa Bahaa Eldeen
AuthorPawluk, Shane Ashley
AuthorWilby, Kyle John
AuthorRachid, Ousama
Available date2022-03-24T11:00:25Z
Publication Date2022-03-20
Publication NameInternational Journal of Clinical Pharmacy
Identifierhttp://dx.doi.org/10.1007/s11096-022-01390-y
CitationSoliman, A.B.E., Pawluk, S.A., Wilby, K.J. et al. The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies. Int J Clin Pharm (2022). https://doi.org/10.1007/s11096-022-01390-y
ISSN2210-7703
URIhttp://hdl.handle.net/10576/29012
AbstractCritical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types. However, limited guidance exists for critical appraisal of clinical pharmacokinetic studies. We aimed to achieve experts' consensus regarding the quality markers for clinical pharmacokinetic studies in an attempt to develop a critical appraisal tool. Quality markers related to clinical pharmacokinetic studies, were derived from the published literature and categorized according to manuscript reporting domains (abstract, introduction/background, methodology, results, discussion, and conclusion). Questions that aid in appraising pharmacokinetic studies were formulated from these quality markers. Experts were involved in a modified Delphi process to achieve a consensus regarding the formulated questions. The proposed tool was pilot tested on 30 recently published clinical pharmacokinetic studies. Inter-observer agreement was measured to determine the reliability of the included items. Twenty-five experts consented to participate. Three rounds of a modified Delphi survey were required to generate a consensus for a 21-item tool aimed at appraising the quality of clinical pharmacokinetic studies. When applied to 30 recently published clinical pharmacokinetic studies, most items scored fair to moderate levels of agreement (61.90-95.24%). The clinical pharmacokinetic critical appraisal tool (CACPK) developed in this study consisted of 21 items aimed at helping an end-user to determine the quality of a pharmacokinetic study. Further studies are warranted to reaffirm the validity and reliability of the CACPK tool.
SponsorOpen Access funding provided by the Qatar National Library.
Languageen
PublisherSpringer
SubjectClinical pharmacokinetics
Critical appraisal
Critical appraisal tool
Pharmacokinetics
Quality markers
Reporting checklist
TitleThe use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies.
TypeArticle
ESSN2210-7711
dc.accessType Open Access


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