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المؤلفZughaier, Susu
المؤلفWu, Xiaomeng
المؤلفChen, Jen
المؤلفZhao, Yiping
تاريخ الإتاحة2022-03-31T08:51:54Z
تاريخ النشر2020
اسم المنشورJournal of Emergency Medicine, Trauma and Acute Care
المصدرqscience
الاقتباسZughaier S, Wu X, Chen J, Zhao Y. Rapid detection of bacterial infections using nanotechnology-based point-of-care sensor with Raman spectroscopy, Journal of Emergency Medicine, Trauma & Acute Care, Qatar Health 2020 Conference 2020:5 http://dx.doi.org/10.5339/jemtac.2020.qhc.5
الرقم المعياري الدولي للكتاب1999-7086
الرقم المعياري الدولي للكتاب1999-7094
معرّف المصادر الموحدhttps://doi.org/10.5339/jemtac.2020.qhc.5
معرّف المصادر الموحدhttp://hdl.handle.net/10576/29195
الملخصBackground: Mass gathering is a risk factor for infectious diseases transmission. Therefore, rapid detection of infections is highly desirable. The current gold standard approach to detect bacterial infections in clinical samples (biological fluids) requires three days of bacterial culture to obtain the diagnosis and antibiotic sensitivity results1. This approach, although very accurate results in considerable delay in initiating proper treatment which increases the transmission of infection, mainly hospital-acquired infections. Therefore, rapid detection of infection would lead to rapid clinical interventions, which mitigate the spread of infection and support antibiotic stewardship consequently reducing the burden of hospital-acquired infections. The goal of this research is to develop a highly innovative sensor (point-of-care device) for rapid detection of bacterial infections in biological fluids. This project will also focus on identifying unique SERS spectra of bacterial infections commonly associated with mass gathering and early detection of antibiotic resistant bacteria. Methods: The proposed biosensor is a culture-free diagnostic method utilizing nanotechnology-based fabricated silver nanorod arrays (AgNR) as a substrate for the Surface Enhanced Raman Spectroscopy. Results: We reported the proof-of-concept study using this novel SERS-based diagnostic where we showed that rapid detection of bacterial biomarkers in sputum and exhaled breath condensates (EBC) from patients with cystic fibrosis2,3. We further identified unique SERS spectra of various bacterial siderophores and small molecule metabolites. Conclusion: This method is highly sensitive, fast, cheap, and can be implemented at the bedside using a portable (hand-held) Raman spectroscope.
اللغةen
الناشرHamad bin Khalifa University Press (HBKU Press)
الموضوعbacterial infection
biosensor
diagnostic
Raman spectroscopy
العنوانRapid detection of bacterial infections using nanotechnology-based point-of-care sensor with Raman spectroscopy
النوعArticle
رقم العدد3
رقم المجلد2020
dc.accessType Open Access


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