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المؤلفNimir, Hassan
المؤلفAl Mohaideb, Norah
المؤلفHamad, Mariem
المؤلفAli, Awadelkareem
المؤلفAktas, Cenk
المؤلفHuch, Volker
المؤلفVeith, Michael
المؤلفRauch, Uli
تاريخ الإتاحة2022-03-31T08:51:56Z
تاريخ النشر2016
اسم المنشورQatar Foundation Annual Research Conference Proceedings
المصدرqscience
الاقتباسNimir H, Al Mohaideb N, Hamad M, Ali A, Aktas C, Huch V, Veith M, Rauch U. (2016). Synthesis, Characterization, Crystal Structures, and in vitro Antitumor Activity of Palladium and Platinum (II) Complexes with 2-Acetyl-4-Methylthiazole Thiosemicarbazone and 2-Acetylpyrazine Thiosemicarbazone. Qatar Foundation Annual Research Conference Proceedings 2016: HBPP3347 http://dx.doi.org/10.5339/qfarc.2016.HBPP3347.
الرقم المعياري الدولي للكتاب2226-9649
معرّف المصادر الموحدhttps://doi.org/10.5339/qfarc.2016.HBPP3347
معرّف المصادر الموحدhttp://hdl.handle.net/10576/29211
الملخصThe novel Schiff bases I HAMTTSC (2-Acetyl-4-methylthiazole thiosemicarbazone), II HAPTSC(2-Acetylpyrazine thiosemicarbazone) and their complexes with Pt(II) and Pd(II): 1 [Pt(AMTTSC)Cl], 2 [Pt(AMTTSC)2], 3 [Pd(AMTTSC)Cl], 4 [Pd(AMTTSC)2], 5 [Pt(APTSC)Cl], 6 [Pt(APTSC)2], 7 [Pd(APTSC)Cl], and 8 [Pd(APTSC)2] have been synthesized, and characterized by elemental analysis and spectroscopic studies. The crystal structure of the Schiff bases I, II, and the complex 1 [Pt(AMTTSC)Cl], have been solved by single-crystal X-ray diffraction. The electronic, IR, UV/Vis, and NMR spectroscopic data of I and II and their complexes are reported. The in vitro antitumor activity of the Schiff bases and 1, 2, 4, 5 and 6 complexes against two different human tumor cell lines (HT-29 and HuTu-80) reveals that the complexes are more cytotoxic than their corresponding ligands with IC50 values at the range of 0.1-10 ?M. These compounds can therefore be considered as agents with potential antitumor activity. Molecular structure of 1 [Pt(AMTTSC)Cl]
اللغةen
الناشرHamad bin Khalifa University Press (HBKU Press)
الموضوعPalladium and Platinum (Ii)
Antitumor
العنوانSynthesis, Characterization, Crystal Structures, and in vitro Antitumor Activity of Palladium and Platinum (Ii) Complexes with 2-Acetyl-4-Methylthiazole Thiosemicarbazone and 2-Acetylpyrazine Thiosemicarbazone
النوعConference Paper
رقم العدد1
رقم المجلد2016
dc.accessType Open Access


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