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AuthorNimir, Hassan
AuthorAl Mohaideb, Norah
AuthorHamad, Mariem
AuthorAli, Awadelkareem
AuthorAktas, Cenk
AuthorHuch, Volker
AuthorVeith, Michael
AuthorRauch, Uli
Available date2022-03-31T08:51:56Z
Publication Date2016
Publication NameQatar Foundation Annual Research Conference Proceedings
Resourceqscience
CitationNimir H, Al Mohaideb N, Hamad M, Ali A, Aktas C, Huch V, Veith M, Rauch U. (2016). Synthesis, Characterization, Crystal Structures, and in vitro Antitumor Activity of Palladium and Platinum (II) Complexes with 2-Acetyl-4-Methylthiazole Thiosemicarbazone and 2-Acetylpyrazine Thiosemicarbazone. Qatar Foundation Annual Research Conference Proceedings 2016: HBPP3347 http://dx.doi.org/10.5339/qfarc.2016.HBPP3347.
ISSN2226-9649
URIhttps://doi.org/10.5339/qfarc.2016.HBPP3347
URIhttp://hdl.handle.net/10576/29211
AbstractThe novel Schiff bases I HAMTTSC (2-Acetyl-4-methylthiazole thiosemicarbazone), II HAPTSC(2-Acetylpyrazine thiosemicarbazone) and their complexes with Pt(II) and Pd(II): 1 [Pt(AMTTSC)Cl], 2 [Pt(AMTTSC)2], 3 [Pd(AMTTSC)Cl], 4 [Pd(AMTTSC)2], 5 [Pt(APTSC)Cl], 6 [Pt(APTSC)2], 7 [Pd(APTSC)Cl], and 8 [Pd(APTSC)2] have been synthesized, and characterized by elemental analysis and spectroscopic studies. The crystal structure of the Schiff bases I, II, and the complex 1 [Pt(AMTTSC)Cl], have been solved by single-crystal X-ray diffraction. The electronic, IR, UV/Vis, and NMR spectroscopic data of I and II and their complexes are reported. The in vitro antitumor activity of the Schiff bases and 1, 2, 4, 5 and 6 complexes against two different human tumor cell lines (HT-29 and HuTu-80) reveals that the complexes are more cytotoxic than their corresponding ligands with IC50 values at the range of 0.1-10 ?M. These compounds can therefore be considered as agents with potential antitumor activity. Molecular structure of 1 [Pt(AMTTSC)Cl]
Languageen
PublisherHamad bin Khalifa University Press (HBKU Press)
SubjectPalladium and Platinum (Ii)
Antitumor
TitleSynthesis, Characterization, Crystal Structures, and in vitro Antitumor Activity of Palladium and Platinum (Ii) Complexes with 2-Acetyl-4-Methylthiazole Thiosemicarbazone and 2-Acetylpyrazine Thiosemicarbazone
TypeConference Paper
Issue Number1
Volume Number2016
dc.accessType Open Access


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