Direct adaptive disturbance rejection control for sedation and analgesia
المؤلف | Padmanabhan, R. |
المؤلف | Meskin, Nader |
المؤلف | Haddad, W.M. |
تاريخ الإتاحة | 2022-04-14T08:45:44Z |
تاريخ النشر | 2014 |
اسم المنشور | Middle East Conference on Biomedical Engineering, MECBME |
المصدر | Scopus |
المعرّف | http://dx.doi.org/10.1109/MECBME.2014.6783234 |
الملخص | Patient care in intensive care units involves the combined administration of several drugs. Apart from the desired drug effect, often such drugs disturb other physiological functions of the patient. Control strategies based on nominal pharmacokinetic models cannot ideally embody interpatient and intrapatient variability. Moreover, exogenous and endogenous disturbances also alter physiological parameters of the patient which in turn affect the pharmacokinetics and phar-macodynamics of drugs. Such parameter variations directly influence the output drug effect. Thus, a direct adaptive controller that updates control gains in accordance to system uncertainty and system disturbances can account for interpatient and intrapatient variability. This paper proposes a direct adaptive disturbance rejection controller for the continuous infusion of multiple drugs that have interactive effects. As a case study, we investigate the closed-loop control of propofol infusion while considering the synergistic effect of remifentanil. 2014 IEEE. |
راعي المشروع | Qatar National Research Fund |
اللغة | en |
الناشر | IEEE Computer Society |
الموضوع | Biomedical engineering Intensive care units Pharmacokinetics Signal distortion Adaptive disturbance rejection Closed-loop control Continuous infusions Direct adaptive controller Pharmacokinetic model Physiological functions Physiological parameters System uncertainties Physiological models |
النوع | Conference Paper |
الصفحات | 175-179 |
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