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المؤلفMeskin, Nader
المؤلفNounou, H.
المؤلفNounou, M.
المؤلفDatta, A.
المؤلفDougherty, E.R.
تاريخ الإتاحة2022-04-14T08:45:47Z
تاريخ النشر2011
اسم المنشورProceedings of the American Control Conference
المصدرScopus
المعرّفhttp://dx.doi.org/10.1109/acc.2011.5990875
معرّف المصادر الموحدhttp://hdl.handle.net/10576/29840
الملخصRecent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme. 2011 AACC American Automatic Control Council.
اللغةen
الناشرInstitute of Electrical and Electronics Engineers Inc.
الموضوعPredictive control systems
Biochemical pathway
Biological phenomena
Dynamical behaviors
Genetic regulatory networks
Intervention strategy
Model-predictive control approach
Research activities
Therapeutic intervention
Model predictive control
العنوانIntervention in biological phenomena modeled by S-systems: A model predictive control approach
النوعConference Paper
الصفحات3519-3523
dc.accessType Abstract Only


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