Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms.
المؤلف | Haidar, Muhammad Ali |
المؤلف | Ibeh, Stanley |
المؤلف | Shakkour, Zaynab |
المؤلف | Reslan, Mohammad Amine |
المؤلف | Nwaiwu, Judith |
المؤلف | Moqidem, Yomna Adel |
المؤلف | Sader, Georgio |
المؤلف | Nickles, Rachel G |
المؤلف | Babale, Ismail |
المؤلف | Jaffa, Aneese A |
المؤلف | Salama, Mohamed |
المؤلف | Shaito, Abdullah |
المؤلف | Kobeissy, Firas |
تاريخ الإتاحة | 2022-04-18T07:42:00Z |
تاريخ النشر | 2022-04-17 |
اسم المنشور | Current Neuropharmacology |
المعرّف | http://dx.doi.org/10.2174/1570159X19666211202123322 |
الاقتباس | Haidar Ali Muhammad *, Ibeh Stanley*, Shakkour Zaynab , Reslan Amine Mohammad , Nwaiwu Judith , Moqidem Adel Yomna , Sader Georgio , Nickles G. Rachel, Babale Ismail , Jaffa A. Aneese , Salama Mohamed , Shaito Abdullah*, Kobeissy Firas*, Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms, Current Neuropharmacology 2021; 19() . https://dx.doi.org/10.2174/1570159X19666211202123322 |
الرقم المعياري الدولي للكتاب | 1570-159X |
الملخص | Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least partly, via signals initiated by injured neurons. Activated microglia, thereby, contribute to both neuroprotection and neuroinflammation. However, sustained microglial activation initiates a chronic neuroinflammatory response which can disturb neuronal health and disrupt communications between neurons and microglia. Thus, microglia-neuron crosstalk is critical in a healthy brain as well as during states of injury or disease. As most studies focus on how neurons and microglia act in isolation during neurotrauma, there is a need to understand the interplay between these cells in brain pathophysiology. This review highlights how neurons and microglia reciprocally communicate under physiological conditions and during brain injury and disease. Furthermore, the modes of microglia-neuron communication are exposed, focusing on cell-contact dependent signaling and communication by the secretion of soluble factors like cytokines and growth factors. In addition, how microglia-neuron interactions could exert either beneficial neurotrophic effects or pathologic proinflammatory responses are discussed. We further explore how aberrations in microglia-neuron crosstalk may be involved in central nervous system (CNS) anomalies, namely: traumatic brain injury (TBI), neurodegeneration, and ischemic stroke. A clear understanding of how the microglia-neuron crosstalk contributes to the pathogenesis of brain pathologies may offer novel therapeutic avenues of brain trauma treatment. |
اللغة | en |
الناشر | Bentham Science Publishers |
الموضوع | CNS Injury cellular crosstalk microglia phenotypes microglia-neuron interaction microglial activation neuroinflammation |
النوع | Article Review |
رقم المجلد | 19 |
ESSN | 1875-6190 |
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