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AuthorSharifi M.
AuthorBai Q.
AuthorBabadaei M.M.N.
AuthorChowdhury F.
AuthorHassan M.
AuthorTaghizadeh A.
AuthorDerakhshankhah H.
AuthorKhan S.
AuthorHasan, Anwarul
AuthorFalahati M.
Available date2022-05-21T10:18:27Z
Publication Date2021
Publication NameJournal of Controlled Release
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.jconrel.2021.03.026
URIhttp://hdl.handle.net/10576/31270
AbstractThe bioprinting technique with specialized tissue production allows the study of biological, physiological, and behavioral changes of cancerous and non-cancerous tissues in response to pharmacological compounds in personalized medicine. To this end, to evaluate the efficacy of anticancer drugs before entering the clinical setting, tissue engineered 3D scaffolds containing breast cancer and derived from the especially patient, similar to the original tissue architecture, can potentially be used. Despite recent advances in the manufacturing of 3D bioprinted breast cancer tissue (BCT), many studies still suffer from reproducibility primarily because of the uncertainty of the materials used in the scaffolds and lack of printing methods. In this review, we present an overview of the breast cancer environment to optimize personalized treatment by examining and identifying the physiological and biological factors that mimic BCT. We also surveyed the materials and techniques related to 3D bioprinting, i.e, 3D bioprinting systems, current strategies for fabrication of 3D bioprinting tissues, cell adhesion and migration in 3D bioprinted BCT, and 3D bioprinted breast cancer metastasis models. Finally, we emphasized on the prospective future applications of 3D bioprinted cancer models for rapid and accurate drug screening in breast cancer.
Languageen
PublisherElsevier B.V.
Subject3D bioprinting
Breast cancer
Drug screening
Polymeric and composite scaffolds
Stromal components
Tumor models
Title3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy
TypeArticle
Pagination137-147
Volume Number333
dc.accessType Abstract Only


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