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المؤلفHussain A.
المؤلفHasan, Anwarul
المؤلفBabadaei M.M.N.
المؤلفBloukh S.H.
المؤلفEdis Z.
المؤلفRasti B.
المؤلفSharifi M.
المؤلفFalahati M.
تاريخ الإتاحة2022-05-21T10:18:29Z
تاريخ النشر2020
اسم المنشورJournal of Molecular Liquids
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.molliq.2020.114053
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31291
الملخصNanoparticles (NPs) have been continuously utilized for different implementations, most particularly for cancer drug delivery. A large number of NP-based drug delivery systems (DDSs) have been explored for cancer therapy and a variety of materials have been investigated as potential drug delivery materials to ameliorate the therapeutic potency and harmlessness of anticancer drugs. Proteins NPs like albumin, lactoglobulin and gelatin are considered as outstanding alternatives to be formulated into the nanostructure platforms in conjugation with anticancer drugs because of their safety, biodegradability and biocompatibility. Also, their uncomplicated preparation and modification can be carried out under mild conditions with no concern toward the utilization of hazardous reagents. Therefore, in this paper we present an overview on the different methods for formulation of protein nanostructure including emulsification, simple desolvation/coacervation, complex coacervation (self-assembled), and electrospray. We then review the application of protein NPs especially gelatin NPs (GNPs) as potential candidates in DDSs which can be achieved through internal [pH, matrix metalloproteinase (MMP)] stimuli-responsive smart platforms for cancer therapy. Finally, many of the current challenges, future development of GNPs and their integration into clinical practice were discussed. This paper may pave the way to disclose some details about the healthcare transformation of GNPs toward precision medicine
اللغةen
الناشرElsevier B.V.
الموضوعCancer therapy
Drug delivery
Gelatin nanoparticle
Nanoformulation
Protein nanostructure
العنوانApplication of gelatin nanoconjugates as potential internal stimuli-responsive platforms for cancer drug delivery
النوعArticle
رقم المجلد318
dc.accessType Abstract Only


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