The expression level of angiotensin-converting enzyme 2 determines the severity of COVID-19: lung and heart tissue as targets
Author | Babadaei M.M.N. |
Author | Hasan, Anwarul |
Author | Bloukh S.H. |
Author | Edis Z. |
Author | Sharifi M. |
Author | Kachooei E. |
Author | Falahati M. |
Available date | 2022-05-21T10:18:32Z |
Publication Date | 2020 |
Publication Name | Journal of Biomolecular Structure and Dynamics |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1080/07391102.2020.1767211 |
Abstract | Researchers have reported some useful information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leading to CoV disease 2019 (COVID-19). Several studies have been performed in order to develop antiviral drugs, from which a few have been prescribed to patients. Also, several diagnostic tests have been designed to accelerate the process of identifying and treating COVID-19. It has been well-documented that the surface of host cells is covered by some receptors, known as angiotensin-converting enzyme 2 (ACE2), which mediates the binding and entry of CoV. After entering, the viral RNA interrupts the cell proliferation system to activate self-proliferation. However, having all the information about the outbreakof the SARS-COV-2, it is not still clear which factors determine the severity of lung and heart function impairment induced by COVID-19. A major step in exploring SARS-COV-2 pathogenesis is to determine the distribution of ACE2 in different tissues. In this review, the structure and origin of CoV, the role of ACE2 as a receptor of SARS-COV-2 on the surface of host cells, and the ACE2 distribution in different tissues with a focus on lung and cardiovascular system have been discussed. It was also revealed that acute and chronic cardiovascular diseases (CVDs) may result in the clinical severity of COVID-19. In conclusion, this review may provide useful information in developing some promising strategies to end up with a worldwide COVID-19 pandemic. Communicated by Ramaswamy H. Sarma. |
Language | en |
Publisher | Taylor and Francis Ltd. |
Subject | ACE2 Coronavirus COVID-19 heart lung MERS SARS SARS-CoV-2 |
Type | Article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
This item appears in the following Collection(s)
-
COVID-19 Research [798 items ]
-
Mechanical & Industrial Engineering [1335 items ]