Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats
Author | Hasan, Anwarul |
Author | Kumar, N. |
Author | Gopinathan, A. |
Author | Singh, K. |
Author | Sharma, A.K. |
Author | Remya, V. |
Author | Shrivastava, S. |
Author | Maiti, S.K. |
Author | Mondal, D.B. |
Author | Singh K.P. |
Available date | 2022-05-21T10:18:33Z |
Publication Date | 2016 |
Publication Name | Wound Medicine |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1016/j.wndm.2016.02.003 |
Abstract | Thirty six clinically healthy adult Wistar rats of either sex were used in the study and randomly divided into three groups having twelve animals in each group. Under general anesthesia, a full-thickness skin wound (20 ? 20 mm2) was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with reticulum derived extracellular matrix of bovine origin (b-REM). Healing was evaluated on the basis of wound contraction, gross, haematological, immunological and histopathological observations. On critical analysis of the observed parameters it was found that b-REM has healing potential and shown better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats. |
Language | en |
Publisher | Elsevier GmbH |
Subject | Bovine collagen sheet (b-CS) Bovine reticulum derived extracellular matrix (b-REM) Rats Wound healing |
Type | Article |
Volume Number | 12 |
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Mechanical & Industrial Engineering [1342 items ]