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المؤلفShakya, P.
المؤلفSharma, A.K.
المؤلفKumar, N.
المؤلفVellachi, R.
المؤلفMathew, D.D.
المؤلفDubey, P.
المؤلفSingh, K.
المؤلفShrivastava, S.
المؤلفShrivastava, S.
المؤلفMaiti S.K.
المؤلفHasan, Anwarul
المؤلفSingh K.P.
تاريخ الإتاحة2022-05-21T10:18:34Z
تاريخ النشر2016
اسم المنشورScientifica
المصدرScopus
المعرّفhttp://dx.doi.org/10.1155/2016/2638371
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31332
الملخصAn acellular cholecyst derived extracellular matrix (b-CEM) of bubaline origin was prepared using anionic biological detergent. Healing potential of b-CEM was compared with commercially available collagen sheet (b-CS) and open wound (C) in full thickness skin wounds in rats. Thirty-six clinically healthy adult Sprague Dawley rats of either sex were randomly divided into three equal groups. Under general anesthesia, a full thickness skin wound (20 ? 20 mm2) was created on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with cholecyst derived extracellular matrix of bovine origin (b-CEM). Planimetry, wound contracture, and immunological and histological observations were carried out to evaluate healing process. Significantly (P < 0.05) increased wound contraction was observed in b-CEM (III) as compared to control (I) and b-CS (II) on day 21. Histologically, improved epithelization, neovascularization, fibroplasia, and best arranged collagen fibers were observed in b-CEM (III) as early as on postimplantation day 21. These findings indicate that b-CEM have potential for biomedical applications for full thickness skin wound repair in rats.
اللغةen
الناشرHindawi Limited
الموضوعBubaline Cholecyst Derived Extracellular Matrix
Reconstruction
Rats
العنوانBubaline Cholecyst Derived Extracellular Matrix for Reconstruction of Full Thickness Skin Wounds in Rats
النوعArticle
رقم المجلد2016
dc.accessType Open Access


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