Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe
| Author | Jiang, Y. |
| Author | Liu, S. |
| Author | Zhang, Y |
| Author | Li, H |
| Author | He, H. |
| Author | Dai, J. |
| Author | Jiang, T. |
| Author | Ji, W. |
| Author | Geng, D. |
| Author | Elzatahry, A.A. |
| Author | Alghamdi, A. |
| Author | Fu, D. |
| Author | Deng, Y. |
| Author | Zhao, D. |
| Author | |
| Available date | 2022-05-22T09:12:26Z |
| Publication Date | 2017 |
| Publication Name | Biomaterials |
| Resource | Scopus |
| Identifier | http://dx.doi.org/10.1016/j.biomaterials.2016.11.006 |
| Abstract | Immobilization of a ligand that selectively interacts with cancer cells to nanomaterials can enhance their diagnostic and therapeutic efficiency. In this study, we firstly demonstrate the high expression of receptor for cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) in both mouse and human pancreatic cancer. Based on these findings, sub-50 nm multifunctional superparamagnetic mesoporous nanospheres with surface modified with LyP-1 are rationally designed. Theses nanospheres have a core of silica-protected magnetite nanoparticle and a shell of FITC-labeled mesoporous silica, and they are able to specifically recognize and conjugate with the pancreatic cancer cell in vitro, as verified by the combined techniques of fluorescent imaging and T2 weight magnetic resonance imaging. After systematic administration, these LyP-1 immobilized nanospheres are found to actively target to mouse orthotopic xenograft of pancreatic cancer, which opens up the door for applications in early probing and diagnosis of pancreatic cancer by the multimodal imaging. 2016 Elsevier Ltd |
| Language | en |
| Publisher | Elsevier Ltd |
| Subject | Cells Fluorescence imaging Magnetic resonance imaging Magnetite Magnetite nanoparticles Mammals Mesoporous materials Molecular imaging Nanomagnetics Nanospheres Silica Superparamagnetism Amino acid peptides Combined techniques LyP-1 Mesoporous nanospheres Multi-modal imaging Pancreatic cancers Superparamagnetic nanospheres Therapeutic efficiency Diseases cysteinylglycylasparaginyllysylarginylglycylcysteine fluorescein isothiocyanate LyP 1 magnetite nanoparticle mesoporous silica nanoparticle nanosphere nuclear magnetic resonance imaging agent peptide protein protein p32 unclassified drug contrast medium cyclopeptide LyP-1 peptide magnetite nanoparticle nanocapsule nanoconjugate nanosphere animal cell animal experiment animal model animal tissue Article cancer diagnosis controlled study diffusion weighted imaging drug cytotoxicity drug design female fluorescence imaging human human cell human tissue in vitro study molecular probe mouse multimodal imaging nonhuman nuclear magnetic resonance imaging pancreas cancer pancreatic cancer cell line priority journal protein expression tissue distribution tumor xenograft animal Bagg albino mouse chemistry diagnostic imaging genetic procedures metabolism pancreas tumor pathology porosity procedures reproducibility sensitivity and specificity tumor cell line ultrastructure Animals Cell Line, Tumor Contrast Media Female Magnetite Nanoparticles Mice Mice, Inbred BALB C Molecular Probe Techniques Molecular Probes Multimodal Imaging Nanocapsules Nanoconjugates Nanospheres Pancreatic Neoplasms Peptides, Cyclic Porosity Reproducibility of Results Sensitivity and Specificity |
| Type | Article |
| Pagination | 18-Sep |
| Volume Number | 115 |
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